... they work on different pathways? I know there is no euphoria etc. while taking the combo but will the roxicet actually work for pain while concurrently taking suboxone??
Responses (5)
15 Sep 2010
Naloxone, one of the ingredients in Suboxone, blocks opiates from attaching to the receptors in the brain. The information I read specifically states that suboxone is used to treat opioid addiction. So it's not making much sense to me. I'm sure someone with more knowledge on the specifics of Suboxone will have a more accurate, detailed answer for you.
Chris
15 Sep 2010
No that makes no sense what so ever. Suboxone has both an opiate antagonist & an opiate agonist & it might make you feel some withdrawl feelings if you take the roxicete for awhile (without taking the suboxone) & then take the suboxone or the other way around. I experianced that first hand but in my case I had/have quite a large tolerance & I felt so awful I just laid on my couch not wanting to move,sweating & cold sweats at the same time,it was the worst!! Good luck with that,but I'd mention that to your doc cuz in my case the meds in my system were alot stronger than the oxycodone your prescribed,but you'd think the results would be similar.
Ya, I know... weird, right?? Actually what he prescribed specifically is one 8mg suboxone daily (was already on that for 10 days) then added three 30mg roxicets daily... You only get sick (called precipitated withdrawls) if you take the sub too soon after having been on opiates only, not the case here.. So is he pullin my leg or what? Can you actually get any effective pain relief by taking opiates while you are on subs?? Like I said this guy is no quack. he did somewhat explain it to me..but I cant find ANY info on the net about this ! So I'm stumped!!
I truly would run this past a pharmacist, the TRUE EXPERT on medications. just because the subs will block the high of the r'cet, i am reasonably sure u might still b in danger of an OD. i have seen a post 1 other person said their pm dr. rx'ed subutex and oxy 4 breakthru and no one here thought that was a sane med. decision, and subutex doesn't have the 2nd blocker med, naloxone. i am wondering if he should have taken u off subs and just rx'ed methadone or some other long acting opiate. I have seen the warning more than once that u can OD on subs + opiates. Please ask a pharmacist b4 u take the rox. on top of subs. drs r human they can make mistakes, my daughter and i almost died from 1 major mistake and several small ones.
15 Sep 2010
i don't know if my comment posted, txt answ. from phone. Please run this past a pharmacist, they r the TRUE EXPERTS on all medications, that is all they do is meds. I have seen warning after warning about accidental OD'ing on subs + high doses of opiates on this site. u could run it past robert-325 as well. would u post it if the pharmacist and robert give that a big no? I have only seen 1 other post saying their pm dr. rx'ed subutex and oxy 4 breakthru and it got many negative responses, no positive responses, and subutex doesn't have naloxone in it.
15 Sep 2010
Hi freeme123, I am not on suboxone for pain, but I am on Methadone for chronic pain. You can use other opoid pain reliviers while on this medication. You will still get pain relief from the roxicet, but no euphoria. As long as you are not trying to get high on the roxicet and are only using it for break through pain (which is probably the case) it should offer you some extra pain relief when needed. I hope you are feeling better. Fall Queen
I don't know... Methadone and other opioids you can do, but Suboxone and other opioids is almost always a recipe for disaster. Methadone doesn't have the naloxone in it, and the naloxone very well might make you sick from the addition of any other opioid other than what's in the Suboxone. Just sounds like a new doctor is needed... on top of that, a drug like Methadone is generally considered to be better for long term chronic pain vs. Suboxone. If the doctor tells you that Methadone is far to dangerous, it's only because the doctor dosen't know a thing about Methadone...
JK13, You are right. I don't know enough about Suboxone, but when you posted that it made alot of sense F.Q.
16 Dec 2011
I noticed alot of people are talking about methadone on here, Im going to warn you about it, here is my story, please please please dont ever start methadone, where is why..I was on methadone for almost 2 years, it is the devil drug, It makes you so tolerant to any kind of seditive, even months after getting off of it, also it is the hardest drug to get off of. Even if you do taper slowly off of it you will have the worst withdrawls. Doctors dont tell you any of this when you start it. I want to WARN anyone I can not to take that first methadone. You will be hooked and when you want off of it you will go through hell, you will go through horrible deppression, and you can have siezures, They say if you want to taper to take it down 1 mg a month and that will screw with you so so bad. With Suboxone you take one and you are good for at least 24 hours, Im am perscribed 90 a month and I always have at least 30 to 40 left by the end of the month.
Keep in mind some consider the withdraw from suboxone to be just as bad as other opiates, if you continue taking it. As a matter of fact, suboxone withdraw can last about 4 times longer than normal opiate withdraw, and long term withdraw symptoms are said to last 4-6 months.
I've been off suboxone for a month now, I was taking it for about a year, 8mg a day. The withdraw was awful, and I still don't feel right. Some depression and lack of energy. Because of this, I recommend Sub to nobody. Just go through the withdraw, get over it, and move on with your life. No need to swap one addiction for the next.
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Thanks Christine As I understand it ,my doc said that the naloxone in suboxone only blocks opiates if you try to inject the suboxone . Apparently , the naloxone is not absorbed sublingually. This PM doc is no joke - he is board certified etc etc and many years of experience, large practice, yadayada... Of course ,I asked him my posed question and he said something to the affect of " they each work on different pathways to receptor " and may offer a better pain management option. I dunno , seems odd to me, maybe you just dont feel the energy and euphoria but can still get some type of pain relief action. I see him again next week and I will probe further , but I am very curious to see if anyone else is on this combo, and if indeed it was helpful . I gotta say, its not workin for me so far...
You know this has caused quite abit of thought for me,I read all day long concerning drugs and there affects,its kind of late for that but really, I never just went out and bought drugs off the street for play,until I was physically dependant.
Expand this post...
These pains killers were for ligitament pain,and a surgical procedure,was also used for pain relief.But honestly, what your Doctor says is quite true Ive never heard of Naloxone working anyother way,I just assumed the buprenorphine went straight through the tongue before the naloxone got to your metabolism,and that the bup had time to work before,But now I guess since this dumb A@s doctor of yours has blew the whistle.That is very true ive never heard of naloxone working any other way except intravenously!! And Ive always heard that the bup has a ceiling effect!!I have never really thought about it either.But really if you use a 150 carat diamond purse with a pair of wrangler jeans then what happens?? The purse classes the jeans up.Even though there way out of the class with damonds they still look great!! Whos looking at the jeans,but they sure feel good on whos wearing them?? And thats pretty much what your dealing with.Buprenorphine is the 2nd highest potent drug used in surgerys around the world today, Alot of People dont know this,there are very few stronger drugs than buprenorphine.And that my dear is your diamonds so to speak.So guess you could mix it with "anything" you like and what ever it is,,Its gonna look and feel good on you!! If you get my meaning.From what ve read with opiates you have catagories.#! Thebaine #2 Morphine #3 codeine ,And then you go from there,the dirivitves Which are put into different classes,different combinations and strenths,for what ever purpose its made for.In the beginning from what I understand the bup was like I said for surgerys and now the've concocked this recipe for this use.You hear this bullsh#t about it having a ceiling effect??? Did anyone tell you what catagorie your in??? You have 100 proof jack, boones farm,and budweiser If you have 10 jack and coke vs 10 glasses boones farm,Whats the different level high.Same thing different substances ones opiates and ones alcohol.Your gonna have one effect off of the catagory of 100 proof jack and bup- which comes from thebaine..And then your gonna another effect from the budweiser and oxycodone different level same dirivitive Thebaine,and alcohol of course.When you talk about putting a ceiling effect on 10000000 proof jack,what possible difference would it make on something that D#mn strong,I hope you understand what im trying to say.Your dealng with diamonds not blue jeans how many would it really take to clas those jeans up.Very few real nice ones right?? Compared to say medium rubys??? And IM real sorry that it took me so long to understand this because ive already started taking Suboxone 5 months ago.I jumped from a level of oxycontin which is a dirivtive of oxycodone to buprenorphine??That means that, that 1mgs that everyone is trying to drop to .05 mgs suboxone is like dropping from 40mgs of oxycontin to 20mgs, as bup is 40 times stronger than oxycontin... And so on..you finally get down to a sliver whch is compared to a 5 or 10mgs percocet and by that time your ready to jump... After being so very high on buprenorphine for so long this becomes a walk in the park so to speak..And I would imagine it wll take sometime to get over a high like that,especially 24/7 D#m#.Do you see?? If that doctor would have handed me a double whammy like that,I would have slapped the S#it out of him... Knowing what I know now that to me would be buildng tolerance for both substances at one time!!! What are you suppose to use to get off of that, the" Fentanils" thats the only drug I know of thats stronger than bup and I dont see know body giving any one that for withdrawls. This is my perception of this suboxone,I could be wrong, but I gotta sneaky hunch Im not.And I can asure you after hearing that doctor gave you that combnation I dont doult anything a they would do..I would not take that combination thats fire.You see a doctor could read this and get a bunch of nothing out of it cause he doesent understand the real effects unless hes done it.he would get just about as much out of it as he does his school book!You are the only one that really knows you know more than he'll ever know cause you live it..He just read about it and what it did to rats... And pigeons... White ones at that the scientist bought them here where I live,in s.c.
oxycodone ↔ buprenorphine
Applies to: Roxicet (acetaminophen/oxycodone), Suboxone (buprenorphine/naloxone)
GENERALLY AVOID: Mixed agonist/antagonist analgesics may reduce the analgesic effect of pure opioid agonists and/or precipitate withdrawal symptoms in patients who have received or are receiving a course of therapy with a pure opioid agonist analgesic.
MANAGEMENT: Mixed agonist/antagonist analgesics such as pentazocine, nalbuphine, dezocine, butorphanol, and buprenorphine should generally be avoided or administered with caution to patients who have received or are receiving pure opioid agonists.
Read more: http://www.drugs.com/interactions-check.php?drug_list=72-1133,439-2040#ixzz0zfXV1F2F
oxycodone and buprenorphine both come from thebaine!!! Still sounds kinda shady though.I dont see what purpose that little amount of anything upside buprenorphine would do,outside of as you say possiably hurt someone.I wouldnt take it.
Apparently they can be used together (possible dangers involved) but the question is why? Since the Sub reduces the effectiveness of a pure opioid agonist, like roxicet, why take it at all? Although they CAN be used for other purposes, subs are normally prescribed for people addicted to opiates but wanting off of them. Roxicet is an opiate used ONLY to treat pain. It seems like a complete contradiction. I would definitely ask a pharmacist about this. And you can always seek a second opinion. If you choose to follow this docs advice (I wouldn't) you must at least follow the directions exactly as prescribed.
I forgot to add... you said it wasn't working so far. Don't you think the sub is blocking the opiate?