13 Aug 2010
Checked the Interactions between the 2 meds, and it has been recommended to be monitored:
Applies to: Lipitor (atorvastatin), Valturna (aliskiren/valsartan)
MONITOR: Coadministration with atorvastatin may increase the plasma concentrations of aliskiren. The exact mechanism of interaction is unknown but may involve competitive inhibition of the CYP450 3A4 metabolism of aliskiren. According to the product labeling, peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of aliskiren were increased approximately 50% by atorvastatin following multiple dosing. Aliskiren had no significant effect on the pharmacokinetics of atorvastatin.
MANAGEMENT: Caution is advised during coadministration of aliskiren with atorvastatin. Antihypertensive response should be monitored more closely following initiation, discontinuation, or change of dosage of atorvastatin in patients who are stabilized on their aliskiren regimen. Patients should be advised to notify their physician if they experience excessive adverse effects of aliskiren such as dizziness, lightheadedness, diarrhea, abdominal pain, and gastroesophageal reflux.
Please for technical details talk to the doc who prescribed the med, hope the info helps?
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