... dose? When do the "twitching" symptoms normally start to show up? Is this a rare side effect?
14 Sep 2009
here is what i found from the manufacturer on the standard doseage levels.
Gastroesophageal reflux (unlabeled use): Oral: 0.1-0.2 mg/kg/dose 4 times/day
Antiemetic (chemotherapy-induced emesis) (unlabeled): I.V.: 1-2 mg/kg 30 minutes before chemotherapy and every 2-4 hours
Postpyloric feeding tube placement: I.V.:
<6 years: 0.1 mg/kg
6-14 years: 2.5-5 mg
>14 years: Refer to adult dosing.
Gastroesophageal reflux: Oral: 10-15 mg/dose up to 4 times/day 30 minutes before meals or food and at bedtime; single doses of 20 mg are occasionally needed for provoking situations. Treatment >12 weeks has not been evaluated.
Diabetic gastric stasis:
Oral: 10 mg 30 minutes before each meal and at bedtime
I.M., I.V. (for severe symptoms): 10 mg over 1-2 minutes; 10 days of I.V. therapy may be necessary for best response
I.V.: 1-2 mg/kg 30 minutes before chemotherapy and repeated every 2 hours for 2 doses, then every 3 hours for 3 doses (manufacturer labeling)
Alternate dosing (with or without diphenhydramine):
Moderate emetic risk chemotherapy: 0.5 mg/kg every 6 hours on days 2-4
Low and minimal risk chemotherapy: 1-2 mg/kg every 3-4 hours
Breakthrough treatment: 1-2 mg/kg every 3-4 hours
Oral (unlabeled use; with or without diphenhydramine):
Moderate emetic risk chemotherapy: 0.5 mg/kg every 6 hours or 20 mg 4 times/day on days 2-4
Low and minimal risk chemotherapy: 20-40 mg every 4-6 hours
Breakthrough treatment: 20-40 mg every 4-6 hours
Postoperative nausea and vomiting: I.M., I.V.: 10-20 mg near end of surgery
Postpyloric feeding tube placement, radiological exam: I.V.: 10 mg
Gastroesophageal reflux: Oral: 5 mg 4 times/day (30 minutes before meals or food and at bedtime); increase dose to 10 mg 4 times/day if no response at lower dose
Oral: Initial: 5 mg 30 minutes before meals and at bedtime; increase if necessary to 10 mg doses
I.V.: Initiate at 5 mg over 1-2 minutes; increase to 10 mg if necessary
Postoperative nausea and vomiting: I.M., I.V.: 5 mg near end of surgery; may repeat dose if necessary
Dosing adjustment in renal impairment: Clcr <40 mL/minute: Administer at 50% of normal dose
Hemodialysis: Not dialyzable (0% to 5%); supplemental dose is not necessary
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