Why does Lyrica cause anxiety, depression and even suicidal thoughts in some people? I was first put on Neurontin, which sent me into this black hole of depression, then they put me on Lyrica and I still was severely depressed. Now I'm taking antidepressants together with the Lyrica and it seems to help. Does Lyrica deplete one of serotonin or is it something else playing a role here? Thank you.
12 Sep 2012
Yes, Lyrica can cause anxiety, depression and suicidal thoughts, if you where to experience any of these possible side effects seek medical attention immediately.
Click on the link for more detailed information:
12 Sep 2012
Hello Oldriska. Its your own chemical disposition, the manner that it interacts with the drug. Not unusual. A example is Zoloft. Not know as a drug when taken will put weight on a person. But say a token few do put weight on. Its then recorded as a side effect, and listed as such. Most all the psychiatric drugs carry the side effects you mentioned. Regards pledge
12 Sep 2012
Hi Oldriska, when I started neurontin I had the depression side effect, but the pain relief was so great I thought I'd give it the old college try. After one month the depression and anxiety were gone.
Now I take it for the pain relief with no depression, it works great for me.
It just depends upon a person's individual chemistry like kaismama has said.
Neither deplete serotonin, not that I've found, and I googled this several times, attempting to find an answer for you.
Good luck in finding a pain medication that works for you.
19 Feb 2013
I am currently withdrawaling from lyrica. I have been walking around aimlessly for hours by myself in the middle of the night. I have thought about killing myself several times and I am just so depressed. i have this feeling in my stomach like anxiety but it never goes away. i feel insane and dont know what to do. I had no idea that these were side effects of the drug. Im glad i know that now. I have always been a very depressed person and ive never felt this way before. I cant sleep, im constantly sweating and freezing. When will this stop? please i need to know . i need help
30 Dec 2013
The reason it can increase depression, or have depression as a side effect, might have to do with the fact that it blunts the release of monoamine neurotransmitters. Based on my own experience, it doesn't only boil down to dosage level but also the length of time that you take it. I notice the depression effect came on less quickly and less severely when I quit the med for a few months and went back on it at a lower dosage. However I'm noticing its depression effect is coming on yet again and in a more pronounced way after weeks of taking it. Symptoms include but aren't limited to : lack of interest in anything, lack of appetite, lack of motivation, lack of positive mood. I have depression problems to begin with so there must obviously be an interaction. Coming off of the drug I'm not sure that I notice any withdrawal. If anything those brain-blunting side effects just kind of drag on for a little while after quitting and it takes some time to go back to normal.
Could take a few days, weeks, or months depending on the dosage you were taking and for how long. Luckily there is no issue with dependency or withdrawal on my end.
19 Feb 2014
I am looking into why as well. I experienced being suicidal while taking lyrica. Two seperate occasions. I have always been a depressed person anyway. I blacked out a couple times. Now I have to live with self inflicted humility from overdoseing myself and cutting my wrist. I definitely believe that lyrica played a part. Im doing better now as I am no longer on it. I was only on it for two months. I don't recommend this medication .
21 Mar 2014
I was taking 300mg of gabapentin last yr. I became depressed. My doctor took me off of it although he didn't completely believe it caused my depression. Then my neurologist put me on lyrica. The depression not only lingered it has gotten worse... to the point of suicidal thoughts. I do take other medicine for the depression but none seems to help. I really need to know if lyrica is what could be causing my depression so I can stop it. And how should I stop it?? I'd rather deal with the pain than severe depression.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
I am 27 years old and have suffered from debilitation depression and suicidal thoughts since the age of 8. I have tried over 40 medications for ...
3 answers • 2 Apr 2010
120 mg Cymbalta drank hard liquor over Labor Day Holiday and became severely depressed with thoughts of leaving and plans to commit suicide.
5 answers • 8 Sep 2010
I’m 30 years old and have been dealing with social anxiety, worry, and fear and being so timid all my life. It’s gotten worse lately ...
5 answers • 26 Sep 2011
Suicidal thoughts. Not sure why this is happening now. Not sure if I need a higher dose or is this the wrong med.
2 answers • 6 Dec 2012
I've been on zoloft since may this year for depression and anxiety. I am 17 years old, and female. I originally was taking this with Vistaril, ...
3 answers • 11 Sep 2013