Low Dose PremPro or Activella - what's the difference?

21 Aug 2010

Activella 0.5 mg/0.1 mg tablets contain 0.5 mg of estradiol and 0.1 mg of norethindrone acetate.
PremPro low dose tablets contain 0.3 mg conjugated estrogens and 1.5mg medroxyprogesterone acetate.
They are both very similar and used to treat menopausal symptoms such as hot flashes, vaginal changes (itching, burning, dryness), difficulty or burning with urination and also to prevent thinning of the bones (osteoporosis).
A recent study comparing Activella and Prempro has shown that Activella causes less bleeding than Prempro. One of the biggest problems with Prempro is that women often have breakthrough bleeding and this often causes women to stop taking their medication.
Because of this advantage women may be more likely to continue their hormone replacement therapy if they start with Activella - this may be the reason your doctor is "pushing" Activella.