Can anyone please clarify the the primary difference in PremPro 0.3mg/1.5mg vs. Activella 0.5mg/0.1mg? I was on the low dose PremPro for many years and stopped for one year when my OB-GYN retired. Had night sweats, trouble sleeping, skin lost all elasticity and my hair began to thin noticably. Went on Activella for about a year and got some relief. Recently went back to PremPro, but am afraid of all the very scary effects of either (heart, cancer, etc.). The only side effect I got from the PremPro was some edema in my legs-not horrible-just need to know what the difference is and why my OB-GYN is pushing the Activella over the PremPro. I am 58 years old and have all my original parts. Please advise.