This question has also been asked and answered here: How long does Adderall stay in your system?
12 Sep 2013
XR actually lasts about 10-12 hours for me, even though when I was on Concerta, it lasted about 7 hours max under perfect conditions.
However, if I spend all day trying to be focused on things like studying, driving, playing one game for a long time, etc., it may stop being effective before 10 hours. I can only do so much in one day, and Adderall doesn't fix that.
8 Sep 2012
Adderall XR will be effective in your system for 6 to 8 hours (the drug companies state 12 hours, but I have never known that to be the case for individuals taking XR). Of course this all depends on how you personally metabolism the medication. You would want to take it early in the day so it does not disrupt your sleep - either getting to sleep or staying asleep. Now the half-life of the medication is longer, but I would not be too concerned about that unless you are having some residual effects after that initial period of efficacy. I have taken Regular Adderall, and it didn't affect my sleep if I did not take it too late in the day - of course, I did not receive the benefits of the longer lasting XR because the immediate release form wears off much quicker. I am just wondering what the impetus is for asking your question.
Of course you certainly do not have to reveal that to me - some unknown guy on the Drugs.com forum, but it might help me narrow the focus of my answer to your specific situation. Please let me know, if you feel comfortable in so doing.
All the best,
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