... and have gained six pounds
10 Jul 2014
I was first given samples of this medication for chronic constipation due to IBS and medication (Cymbalta) side effects. I was given the impression then to take Linzess when I needed it (every other day or two - taking something is the only way I can go)so I did and it worked within 2-4 hours of taking it. Perfect, I thought. I could plan around work and other obligations to be near a bathroom. Since it worked well, the doctor have me a prescription and I began taking it according to the official directions of taking it in the morning on an empty stomach. Now I am on day four without a bowel movement. Has anyone else experienced this? Is there anything wrong with taking it later on the day and after I have eaten? I didn't have weight gain using it the way I had been using it and it was effective in getting me to go.
20 Jul 2014
I have been on this medication for one month and I have gained five pounds. At first I couldn't figure it out, because weight gain wasn't a side effect. I work out and eat sensibly, so I was already losing weight, now I'm gaining.. The only thing that I was doing differently was taking this medication. So when I googled "does Linzess cause weight gain", it's nice to know this isn't just in my mind.
27 Nov 2014
Not every experiences weight gain. I am on the high dosage and after 1-2 months I have lost 10-15 lbs. this has Beene miracle drug for me. I have side effects on occasion like lose stool & stomach pain. Over all it's helped me more than anythinng I've ever tried. My issue began shortly after a surgery I gained weight and no matter what I tried nothing would work in getting the weight off. Only lost around 5 lbs working out more often. I have more gas than I did which is bad because I had a lot before. This medicine has helped me so much. I guess it just depends on the person
15 Oct 2014
This has all been helpful. My doc gave me some samples and I wanted to read reviews before taking them. I already suffer from weight gain due to thyroid and don't need any more help with that. I'll try to stay on the dieters tea and prune juice but the cramping is horrible... wish me luck in finding the right regimen of the 2 to live without cramps and without constipation. Any other ideas???
7 Jul 2014
I have been on it for a little over 2 weeks now, the higher dose, and I have actually lost almost 10 lbs. I was suffering from horrible issues for over 6 years old, so since i was 19, and within a couple days of starting the meds my digestive track has never felt better. The constipation was causing my weight gain so this medication has helped. But like any other drug it does not work the same for everyone.
9 Dec 2013
For those of you that have experienced weight gain, which strength are you taking: the lower dose (145 mg) for constipation or the higher dose (290 mg) for IBS? I am taking the higher dose for IBS and have been relatively pleased with it, but I have gained some weight, but it's very possible it's not related to the med - could be hormonal, or could be just eating too much and getting old ;)
5 Sep 2014
I have never been able to go to the bathroom like regular people do. Not even as a kid. I thought Linzess would be the answer to my potty struggles. Granted, it does work fairly well, even though I do get diarrhea, and constipation if I don't go to the bathroom within a certain time frame. The thing is, I have been taking diet pills to lose 30lbs, and was pretty successful until I started this medication. I eat healthy foods and drink plenty of water; I have cut back on the amount I eat, too. I have Zumba class 4X's a week, and school + an internship Monday through Friday. I hardly even get the chance to eat at all, anymore!
So, why did I step on the scale today and find myself 6lbs heavier! How could I have GAINED weight? I figured it has to be this medication causing me to gain weight, since it is the only thing that has change in the past 3 weeks, so I looked online and I found this forum. This explains a lot and lets me know that I'm not alone in this revelation. What I would like to know is: why isn't this side effect listed? I swear I don't remember seeing it in the list of side effects. Now I just have to figure out if I'm willing to keep taking it, or if I go back to using a series of enemas, laxatives, and fiber supplements, again?! What a horrible thing to do to people who already struggle with IBS-C!
11 Apr 2013
Good to see feedback on this medication. It helps me to know what others are experiencing. Been on it for month now. As I noted in earlier post, I had six pound weight gain in first week. Was hoping it was fluid and mostly it was. I always read PI on any Med and was a bit concerned that I was alone in the bloating and weight gain. I even stopped taking it for a few days and stomach was flat again. Pretty much in observation mode now. Will update Dr in next week or so. Since this is one, if not the, last resort Med for me, not sure what will come next.
There may be better forum for this part, but this Med is only one that has relieved C. ( I will move this part if I find one ). It works some days and not others. When does work, it's with six or so trips to bathroom over course of half to one hour and starting within few hours of taking in morning. Dr and PI say take 30 minutes before breakfast on empty stomach. For me, doesn't matter if I take with or without food since get same effect either way. After that bathroom time, little problem for me later in day. Between jobs now, so not sure I can chance taking this if working since when it hits its urgent and time consuming. I may use it intermittently ... like on weekends or when C is most severe. Just would have to decide if the bloating and water retention (even with taking 90 + ounces of water daily) is tolerable. Jury is still out but less than optimistic.
Chronic severe C.
2 colon surgeries in last five yrs. Sigmoid and another piece of colon removed and rectopexy to remedy rectal prolapses.
No obstructions or diverticulitis, but have small rectocele per recent dynamic MRI and ultrasound. No surgery needed.
No gluten or lactose allergies. Tested negative on both.
Have had both biofeedback and physical therapy (including internal and external rectal work) which helped some... more than most things.
Have had SIBO test which was positive and treated with antibiotics. This definitely helped with bloating. Followed this up with prescribed probiotic VSL (heavy duty and expensive, but OTC through pharmacist ) to replenish good bacteria after antibiotics. Long term VSL not continued because no effect on C for me.
Have taken meds and other things with little or no effect: zelnorn, amitiza, different probiotics specifically for C, stool softeners, Magnesium, FODMAP diet which helps a little with pain, various fiber supps Miralax, benefiber, metamucil, acacia senegal etc including various combos of them, enemas and suppositories which sometimes help a little, but mostly enemas don't even come out.
Next steps per my diligent Dr. are allergy testing although allergies unlikely since so hives or breathing issues with food. Tests for intolerances not clinically validated yet according Allergy based medical societies (different results from different labs using same samples and false positives resulting in unnecessary food restriction which could impact nutrition - labs tested include those used by alternative docs and pharmacists.) Still may do blood and stool intolerance testing on my own, not as diagnostic, but as starting point for trying elimination diet (again).
Last resorts per Dr are interstim implant then more surgery if interstim not successful. Doing nothing is not option because of incontinence related to severe C.
9 Sep 2014
I was diagnosed with IBS-C almost a year ago. My symptoms came on over night. One day I was fine the next I was so sick I could barely sit up straight. After going to the dr for weeks they sent me to a gastrointerologist. He deduced, after a colonoscopy, and lots of blood, work what I had. My dr also perscribed me linzess. At first it too worked great, then over time less effectively. I've tried amitiza and every over the counter laxitive I could find. But over all linzess works the best. The side effects are annoying most of the time, and I do sometimes have trouble going even after taking the med but over all im better with it. Weight gain is something ive noticed is a side effect. I thought it was just me even though im on a high fiber diet and eat less than I probably should. I've tried to different diets, and pills but I'm stuck with the extra 10 pounds. My stomach is so bloated all the time, I don't just bloat in my stomach, I bloat every where.
- Linzess Information for Consumers
- Linzess Information for Healthcare Professionals (includes dosage details)
- Side Effects of Linzess (detailed)
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