I've been on tysabri for 1 1/2 and done very well. My dr wants me to take a 3 month drug holiday?

While I have not used this medication myself I have read about it.
There is a serious risk of developing a life threatening brain infection which results in Progressive Multifocal Leukoencephalopathy (PML) with Tysabri use.
"... In patients treated with Tysabri, the risk of developing PML increases with longer treatment duration, and for patients treated for 24 to 36 months is generally similar to the rates seen in clinical trials. There is limited experience beyond 3 years of treatment. There are no known interventions that can reliably prevent PML or adequately treat PML if it occurs. It is not known whether early detection of PML and discontinuation of Tysabri will mitigate the disease."
Read more: http://www.drugs.com/pro/tysabri.html#ixzz0muVGVDnp

Maybe this is the reason your doctor wants you to have a drug holiday.
You should take his advice.

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You may find these patient reviews interesting:
http://www.drugs.com/comments/natalizumab/tysabri.html