300 mg provigil and 4 mg klonopin
2 Jul 2010
clonazepam ↔ modafinil
Applies to: Klonopin (clonazepam), Provigil (modafinil)
Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Modafinil and armodafinil are modest inducers of CYP450 3A4, and pharmacokinetic studies suggest that their effects may be primarily intestinal rather than hepatic. Thus, clinically significant interactions would most likely be expected with drugs that have low oral bioavailability due to significant intestinal CYP450 3A4-mediated first-pass metabolism (e.g., buspirone, cyclosporine, lovastatin, midazolam, saquinavir, simvastatin, sirolimus, tacrolimus, triazolam, calcium channel blockers). However, the potential for interaction should be considered with any drug metabolized by CYP450 3A4, especially given the high degree of interpatient variability with respect to CYP450-mediated metabolism. Pharmacologic response to these drugs may be altered and should be monitored more closely whenever modafinil or armodafinil is added to or withdrawn from therapy. Dosage adjustments may be required if an interaction is suspected.
However for more professional information you should check with your pharmacist/doc who prescribed the meds, hoe this helps?
4 Jul 2010
I currently take a large amount of depressants for varying conditions. Due to the sleepy nature of the depressants - 3mg of Klonopin included in the mix, I need something to keep me awake during the day (looks bad falling asleep at work), so after a few trial and errors, we found that Nuvigil, almost the same thing as Provigil works great! It did slightly decrease the effects of the Klonopin, but not enough to make any adjustments to any of them meds. I know that the dosages are different, but I currently take 250mg, started at 150, and it wasn't enough. I'd give it a shot, and see what happens. Everyone reacts differently to these sorts of meds. Good luck to you!!!
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