17 Aug 2010
"Neurpath-B" is currently purported to be the generic equivalent now commonly substituted for "Metanx." Prior to the marketing of Neurpath-B, the generic equivalent substituted for Metanx was known as "Folast." BOTH of these purported substitutes are/were manufactured by Brookstone Pharmaceuticals, now under ownership of Acella Pharmaceuticals.
Refer to http://www.metanx.com - and click on "Attention Metanx Patients: Important information about your Metanx prescription" located at the top of the page. There you will find letters from the CEO of Pamlab (who manufactures Metanx) regarding serious concerns with the integrity, stability, and safety of the active ingredient XOLAFIN-B (L-methylfolate calcium) found in Acella Pharmaceuticals products (Folast AND Neurpath-B). Pamlab is the competing company in this case (who brought lawsuit against Folast getting it off the market), but the facts and figures do appear to speak clearly to the problem with these purported "generics."
As a Type II diabetic, with neuropathy problems, my husband has been prescribed Metanx for his condition. Starting a couple of years ago, his prescription initiated with Metanx in brand name form because that was the ONLY form available at that time. He experienced improvements during the time he used Metanx and had no problems with the brand name form. Several months ago, when it came time to reorder his prescription, our pharmacy automatically substituted "Folast" which we were certainly willing to try as a cost-cutting measure. However, my husband has NOT found Folast to be as effective for his condition as the Metanx was, and he developed a severe skin rash (allergic reaction) that surfaced concurrently with his last refill of Folast. We cannot know for sure if there was any direct correlation between Folast and the allergic reaction, but there have been enough valid questions raised about the integrity of BOTH Folast and Neurpath-B, that my husband and his doctor have concluded it is NOT in his best interest to take either of those products as substitutes for Metanx. The doctor is now noting my husband's Metanx prescriptions as "Name Brand ONLY; dispense AS WRITTEN."
8 Jul 2010
Please let me first identify myself as a member of the Metanx brand team.
Neurpath B is not an equivalent to Metanx.
One of the primary ingredients in Metanx is Metafolin (as L-methylfolate calcium), the pure stable crystalline form of folate preferred by the body http://www.metafolin.com/.
Neurpath B features Xolafin, which is supplied from China. This manufacturer is not cGMP (current Good Manufacturing Practices) certified by Chinese or U.S. governments.
Independent laboratory testing demonstrates that Xolafin, when incorporated into the same formula as Metanx is unstable, and falls out of specification in the first month.
To learn more please visit the following link and view the correspondence sent to wholesalers and retail pharmacies: http://www.metanx.com/
We understand the value and quality of pharmaceuticals is critical to you and we wanted to provide you with this information.
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