Is longterm usage of diflucan difficult for the liver?

19 May 2010

Your new doctor is correct.

This is from http://www.drugs.com/pro/diflucan.htm

"... Warnings

(1) Hepatic injury: Diflucan should be administered with caution to patients with liver dysfunction. Diflucan has been associated with rare cases of serious hepatic toxicity, including fatalities primarily in patients with serious underlying medical conditions. In cases of Diflucan-associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex, or age of the patient has been observed. Diflucan hepatotoxicity has usually, but not always, been reversible on discontinuation of therapy. Patients who develop abnormal liver function tests during Diflucan therapy should be monitored for the development of more severe hepatic injury. Diflucan should be discontinued if clinical signs and symptoms consistent with liver disease develop that may be attributable to Diflucan."