Is it recommended to use two different sleep drugs to help prevent tolerance and dependence problems

8 Feb 2012

Sounds like a good idea but I doubt that it will prevent you from developing a tolerance and/or dependency as you are still going to build a certain level of these medications in your system. It really depends on the medication and the half life, but not sure that your plan will really work.

8 Feb 2012

This is a technique most often utilized in europe with opioid type medications. For reasons unknown to me this is a practice not utilized in the US. This is also the first time that I've heard of this rotation used with a non opioid type drug. I know that the goal also is usually to help prevent tolerance and an increasing dose. I have not heard of this either used to prevent dependence.

9 Feb 2012

I honestly dont see how this would work as you are still taking the drugs on a regular basis and in taking them on a regular basis, you build tolerance and dependence. I dont think alternating every other night is spacing them far enough apart to prevent tolerance or dependence to either drug.