Is amitiza habit forming?

Question is Closed Report Mark as Favorite

Answers (1)

15 Sep 2009

with much reading on wiki and the official drug website i have found not a word to lead me to believe it is habit forming in any way as well i found this little tidbit as a am writing this response.

Pharmacokinetics:
Unlike many laxative products, Lubiprostone does not show signs of tolerance, dependency, or altered serum electrolyte concentration. There was no rebound effect following withdrawal of treatment, but a gradual return to pre-treatment bowel movement frequency should be expected.

Minimal distribution of the drug occurs beyond the immediate GI tissues. Lubiprostone is rapidly metabolized by reduction/oxidation, mediated by carbonyl reductase. There is no metabolic involvement of the hepatic cytochrome P450 system. The measurable metabolite, M3, exists in very low levels in plasma and makes up less than 10% of the total administered dose.

Data indicate that metabolism occurs locally in the stomach and jejunum.

Votes: +0

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

Habit-forming traits aside, are there any benefits to taking benzodiazepines over SNRI's or SSRI's?

I am well aware of the habit forming qualities of benzodiazepines and SNRI /SSRI medications. Considering the detriment of the former, is there any ...

2 answers 10 Oct 2009

Nuvigil - a miracle pill but am worried that it will be habit forming etc, anyone else concerned?

I am taking 150 mg of nuvigil for extreme tiredness from sleep apnea. I works like a miracle pill but I am worried about it being habit forming and ...

2 answers 14 Nov 2011

How long will it take Amitiza to work?

I have been taking Amitiza for 2 weeks with now movements at all what can i do different?

2 answers 23 Dec 2012

Medication - Is Seroquel habit forming?

I take 200 mg of seroquel and 2mg of klonopin and 150 mg vistirl a day I know that the klonopin is habitt forming and addictive i am asking. If ...

1 answer 11 Mar 2013

Is promethizine habit forming?

0 answers 13 Feb 2014