Ipratropium - Mechanism of action?
- 22 Sep 2009 by Kerrydolly
- ipratropium, chronic obstructive pulmonary disease, maintenance
22 Sep 2009
Ipratropium bromide monohydrate. It is an anticholinergic bronchodilator, chemically related to atropine.
Ipratropium bromide is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) that are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle.
The bronchodilation following inhalation of Ipratropium bromide is primarily a local, site-specific effect, not a systemic one. Much of an administered dose is swallowed but not absorbed, as shown by fecal excretion studies.
- Ipratropium Information for Consumers
- Ipratropium Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ipratropium (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Chronic Obstructive Pulmonary Disease, Maintenance - can someone please tell me about mometasone and
... it's use with to treat COPD, why it's prescribed, desired effect and side effects?
1 answer • 22 Jul 2009
2 answers • 24 Jun 2011
Chronic Obstructive Pulmonary Disease, Maintenance - Has anyone tried using Quercetin (500mg 3xd) as
... a natural treatment for COPD? I'm into the holistic approach as much as possible. I just started Daliresp, but I'm wary of the extreme ...
5 answers • 8 Oct 2012
... with COPD. Like a support group?
0 answers • 23 Oct 2014