Ipratropium - Mechanism of action?

Answers (1)

22 Sep 2009

Ipratropium bromide monohydrate. It is an anticholinergic bronchodilator, chemically related to atropine.

Ipratropium bromide is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.

Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) that are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle.

The bronchodilation following inhalation of Ipratropium bromide is primarily a local, site-specific effect, not a systemic one. Much of an administered dose is swallowed but not absorbed, as shown by fecal excretion studies.

http://www.drugs.com/pro/ipratropium.html

Votes: +1
Marvell 22 Sep 2009

I hope the above answers your question.

Kerrydolly 23 Sep 2009

Thanks a lot. U have helped a lot. Pls keep in touch!

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

Chronic Obstructive Pulmonary Disease, Maintenance - I am using Spiriva, Zopenex nebulizer 4times a?

... day,Proventil HFA, & Symbicort. I wonder if this is a little to much ?

2 answers 7 Aug 2009

What happens when my husband over doses on Albuterol?

He has COPD and is oxygen dependent. Lately he has been needing to take extra Albuterol-Ipratropium because he gets extremely winded just going to ...

4 answers 6 Feb 2011

Chronic Obstructive Pulmonary Disease, Maintenance - does anyone out there retain co2?

... copd,high levels and what can we do? My husband has copd and has been having symtoms for awhile of retaining co2. He's going to be on qvar ...

2 answers 9 Dec 2011

Can Brovana be used in addition to Tudorza?

I have been on regimen of Xopenex, Budesonide, Ipratropium bromide I have COPD, IPF, CHRONIC BRONCHITIS, the diseases are progressing rapidly and ...

1 answer 22 May 2013