... anti-depressants did go away, meaning I was able to have orgasms again, which was wonderful. However, by the sixth week I couldn't stop crying for four days, my rage had returned for the first time in 20 years, and my ability to have orgasms had also disappeared by the fourth week. I had become manic and was considering checking into a hospital. I am back on Effexor and doing fine. I'll take stability and good mental health over orgasms any day. It was terrifying, really, really terrifying to be that out of control. Make sure you see your doctors frequently. My whole personality completely changed