I wasn't thinking and took the tramadol before double checking for drug interactions. Is 200mg high for Zoloft?
27 Oct 2010
Generally the recommended dosage of Zoloft recommend for adults with depression or obsessive-compulsive disorder is 50 mg once a day. Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, docs often increase that dose to 50 mg daily.
Applies to: Zoloft (sertraline), tramadol
GENERALLY AVOID: The coadministration of selective serotonin reuptake inhibitors (SSRIs) with tramadol, which has weak serotonin reuptake inhibiting effect, may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors. Patients receiving this combination may also have an increased risk of seizures. Pharmacokinetically, coadministration with certain SSRIs, namely fluoxetine, paroxetine and possibly sertraline, may result in decreased plasma concentrations of the active O-demethylated (M1) metabolite of tramadol due to inhibition of CYP450 2D6, the isoenyzme responsible for the formation of the metabolite. The clinical significance of this potential interaction is unknown. However, M1 is thought to possess up to 6 times the analgesic effect of tramadol, thus diminished therapeutic response to tramadol should be considered.
MANAGEMENT: In general, the concomitant use of SSRIs and tramadol should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Patients treated with the combination should be closely monitored for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
However, please seek medical advice from your doc who prescribed the meds, take care, be well & safe!
28 Oct 2010
While zoloft 200mg is a high dose, Drs. will often begin at a lower dose and gradually increase it if necessary. So 200mg isn't too high in regards to zolfot administration ( unless that were the starting dose... I'm assuming you started at a lower dose and your doc gradually increased it).
While it is not recommended to use zoloft and tramadol at the same time, Drs. weight the risk/benefit factor. In your case the Dr. may feel the benefit outweighs the risk. You need to be able to trust your Dr. and his/her treatment. If you have concerns make an appointment and talk to them, and they can tell you why they have prescribed these two meds together, and address you zolfoft doze as well.
One thing though, you didn't say the Dr. prescribed the tramadol, only that you took it... was it prescribed? And re: the tramadol, that's a very low dose.
Hope this helps,
26 May 2012
Well, this may not be of much help.
Im on 200mgs of Tramadol from P.M. Dr. Who is a new Dr for my back injuries,fusion,etc. I left the oxycodone,morphine Dr last month.
In conjunction my new pm Dr knows my primary has me on 100mgs of Zoloft a day & 10mgs Ritalin 2x day.
Am i in trouble? Oh, & a Testosterone shot once a week.
Im 47 w severe CFS and chronic spine pain.
Thought I had researched my meds well, but, a re research sounds advisable.
5 Aug 2013
I have been taking Tremodol for about 2 months now, I went to the doctor a few days ago and she allowed me to increase it to 2 -50 mg tablets 3 times a day. I also take a prescribe alive with this of 500 mg 2x times a day, I was also having mood swing issues, being annoyed and edgy and to be honest a bit bitchy. So the doctor put me on an antidepressant. At the pharmacy they mentioned a saratonen issue and now I am afraid to take any of this. I am waiting for the doctor to call back, I stopped taking all the pain meds and never took the antidepressant. I am unsure what to do and where to turn. After reading all the responds to questions here I am just plan afraid to trust the drug or the medical professionals.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Is Buspar and Zoloft ok to take together ? Is Anyone on this combination ? Drug interaction checker?
... say it a Major drug interaction between these two. My doctor prescribed me Buspar yesterday to take twice a day along with the Zoloft. Any ...
3 answers • 13 Jan 2012
... celecoxib is known to decrease CYP2D6 activity, if taken together, then wouldn't tramadol be metabolized slower, creating a possible ...
1 answer • 8 Mar 2012
I'm worried about serotonin syndrome so should I take 25 mg Zoloft instead of 50 on days I need to take tramadol? I have torn disc that's ...
8 answers • 27 Jul 2014
I spent six weeks on Brintellix, increasing the dose from 10mg. to 20mg. at four weeks. No anti-depressant has ever made me so sick. I looked it up ...
6 answers • 30 Sep 2014