I have just been switched to estratest 3 weeks ago from premarin . Was on premarin for 28 years with no side effects. now headache every day and 5 pds in 3 weeks. My acid reflux is really suffering with estratest. Would like anyones opinion on which hormone is better in the long run, Found lump in breast this year but was not cancer thank god but if premarin is the safer forget the sex drive I can do with out that:) Still checking breast every 6 months thanks