I have tried Cymbalta but couldnt take it due to side effects of extreme edema in my hands, feet and face. I have tried Lyrica and gabapentin too but cant take either of those due to unpleasant side effects.I am wanting to find out if most of you who take an antidepressant/anticonvulsant think it has helped your pain levels and what meds are best to help reduce pain besides opioids and muscle relaxants.
I have been wondering about asking my pain doctor to prescribe an anti-depressant to help with pain?
- Posted:
- 3 Mar 2011 by DzooBaby
- Topics:
- cymbalta, lyrica, depression, migraine, peripheral neuropathy, anxiety, pain, restless legs syndrome, back pain, fibromyalgia, neuralgia, periodic limb movement disorder, gabapentin, edema, side effect
Responses (32)
3 Mar 2011
Years ago, my significant other went on Lorazepam for anxiety and depression. One of its' side effects is effective pain relief, or so he's discovered. (He has an injured disc in his lower back.) Another one is it makes a great sleeping pill. (He used to toss and turn from anxiety and stress, reliving the day, or his 'to-do' list.)
Lorazepam is highly addictive and strictly controlled, so you might have a difficult time getting it, but if all else fails, it might be worth pursuing. I have been on antidepressants my entire life. As an antidepressant, some work for me, and others don't. It depends on individual chemistry. As a pain killer, I have yet to find an antidepressant that will do double-duty for me. =(
I've never tried Lorazepam myself, and my doctor won't give it to me. If you choose to try it, I wish you much success, but always use as little as possible. My s/o breaks his tabs in half, and they still do the trick. Good luck!
3 Mar 2011
if you take those meds how can you think the anti depressant is a pain killer... i would recommend talking to your family (practisioner/ pain clinic) they may suggest marijawana because from what i know of weed it kills the pain and while im high i dont care if other things are around me so it covers both issues you were talking about... and with the green card it is leagal but i would ask them alot of question before getting the card... (may cause issues from the public) just cuz its leagal dont mean it still has no repurcusions from out siders.
example:
freind of court if you have kids might like to know that (repercusion possable).
A legal prescription for marijuana might help with severe chronic pain; that's true. For me, it would be my absolute last line of defense. There's too much stigma and too many social repercussions, as you say.
You have to realize that many drugs serve more than one purpose. Viagra comes to mind. It was never intended to be used as a medication for erectile dysfunction. But because, as a side effect, it worked tremendously in that department, it is now highly marketed as an effective treatment for ED. And that's just one small example of a drug with more than one use!
Some antidepressants WILL control pain. Not to mention that chronic pain can lead to other health problems, like depression. So, if a doctor/pain specialist will entertain using an antidepressant as a pain reliever, I personally think it's worth exploring the possibility.
Another dual-purpose medication just came to mind. Risperdal (an antipsychotic) calms the mind so that you can slow down your thoughts and think things through with more clarity, but taken in a not-very-big dose, will also help you fall asleep very quickly. (I have a family member who uses it for bi-polar and schizoaffective symptoms.) But you really need to see a qualified medical practitioner who can make the best diagnoses and prescribe the most effective, safest treatment, no matter what the illness or symptoms!
3 Mar 2011
Hey DzooBaby,
The first ones that come to my mind are the ones you already tried like Cymbalta, Lyrica and gabapentin. The others that come to mind are old style antidepressants called tricyclics such as amitriptyline or nortriptyline. Another one that may be of use is Savella, it is used for fibromyalgia patients.
Plug these three suggestions into the drug finder or google them and see what you think.
Hope this helps,
Laurie
Yes, Amitriptyline! Good suggestion, Laurie! I knew there was another one to consider, but I just couldn't remember its' name. Amitriptyline can be very effective for some people, and it's not regulated as strictly as some of the other ones, either.
Thanks Laurie!
3 Mar 2011
Hi I know people it has helped but if it was me I would just try to deal with it . I am weening off Effexor right now and it is not fun. If your doctor feels that some drug would help and you can't deal with the pain than I guess you would have to go on something. All I can say is ask questions remember it is your body these medications are going into. If I had known how bad it would be to ween myself off of effexor I would of not taken it.
I have been trying to deal with it for some time but I'm getting very frustrated and tired of hurting so badly all the time. I already take a long acting opioid and a short acting one for breakthrough. I was doing weel until they switched the formula on the long acting med and now I'm stuck with dealing with unrelenting pain. I really dont want to up my opioid dosage. I have mentioned trying something different in the long acting drug but so far he is not willing to change it. I was just wanting to know what others have had success with.
antidepressants have never had any helping effect on my pain. i think thats why theyre antidepressants and pain killers are called pain killers. yes having chronic pain does greatly contribute to depression i believe. i dont recommend taking something for anthing other than its prescribed for.
3 Mar 2011
Vincent 905 I totally agree with you, these drugs are ok when you go on them but trying to come of some of them can be horrible. Not long ago I came of some strong meds and so glad I did, although I do have more pain but it outways how clear I am thinking now and much stronger being able to say no to things I don't want to be on.
So Dzoobaby good luck with finding pain relief, one thing I am trying is accupuncture which I haven't tried before. I was trying it for my Migraines, I have only had 3 sessions but have been told if after 6 I have no change it probably wont work. But it should help with my chronic pain down the road, Just a thought!!!
I've never tried accupunture either. Let me know how it works out. At this point I'll try almost anything!!
Vincent 1905 I am a person who doesn't like needles and trust me when I say it really doen't hurt, some of the needles sting a little but do not hurt. It's worth a try as like yourself I was running out of things to try until my Neurologist put me in touch with the Accupuncturist. Good luck!!
4 Mar 2011
Dzoobaby! I am so surprised by your question! (And I'm not being a smart a--)You answer so many questions about pain problems, & are right on the money so to speak. Are you getting any good sleep? It is so important with Fibromyalgia. I have your problems with side effects too so I know where you are coming from there. My hubby takes Gabepentin for his pain & it really helps him, but didn't me. I had side effects with Lyrica also, but it helped so much I walked around all swelled up for quite a while before I gave up on it. We both take Methadone for the chrontic pain we have, & he takes Zoloft for his depression at 100mg a day. I just asked him if this has helped with his pain at all & he told me no. I was prescribed Elavil years ago when I was first diagnosed with Fibromyalgia by a rheumatologist to take at bedtime to help me sleep & I can't say it helped the pain at that time. This way before Methadone came on the scene.
mary632009,
hi ,
have u tried fentanyl patches ?i've been on them for about two months now ,can't say i'm pain free but i'm as close as i think i'll ever be!i'm on soma's and ultrams for my fibro pain !and i have 15mg of oxy's and fentanyl citrate for break through pain !of course if u don't have insurance this is expensive meds !just trying to help you some with meds that have worked for me !good luck and God bless
Hi DZooBaby,
You've helped me a great deal as well. I agree with Laurie on this one. Ask your doc for amytr... oh forget it, I can't spell it right now! 'Tis 2:15 am, and I've insomnia girl !!
Also, you probably do not want to add anything in the mix, but a benzo like Valium might help with the pain. I've read that it is great for muscle spasms and fibro symptoms. I know that you are quite educated regarding meds, so I really do not need to address addiction factor about benzo's.
Hope and pray you find relief my friend.
4 Mar 2011
Not really, I as you know am on celexa/klonopin, I have felt many a relief in so many areas since being on these meds but as for pain it is a trial and error thing, and as the medical association, fda, and pharmacists alike crack down on the prescrib of many medications for fear of overdose or addiction it is a small war within itself... chronic back pain sufferer, neck pain and now left arm for the past 3 days... alot of stiffness... use alot of heat compresses, baths, and low, low, impact excercise for the meantime... I have not been on any pain med's now for almost 2 years now but don't know how long I can endure... speak with your med professional and see what they say... but as for this psych med being good for pain I can't say I see much diff in that area other than less headaches... blaze22
DZOOBaby
Are we talking migraine pain or Fibro pain? If Migraine pain, I use Stadol Nasal Spray 10mg if my Axert med does not work.
If Fibro pain, a sleeping med called Ambien CR knocked out all my fibro pain within 3 months, went off the Ambien, am sleeping fine and the Fibro did not come back, that been about 6 months ago.
22 Sep 2011
I had a terrible time on and then getting off-codeine and the tramadol and then was on a low dose of amiltriptilyne (yes,I did get that spelling wrong ) for over a year and have just started Lyrica whilst still on the amiltriptilyne. The amiltriptilyne works for me better then any of the other medications and I would like to get back to just that.
22 Sep 2011
@Brendafain, i would not suggest anyone that is faint of heart to get on fentanyl patches unless u plan on being on it for the rest of ur life. I was on it for 2 years and was sick (throwing up constantly) for 3 months straight and lost 30lbs. I was taken off it 4 months ago, it was one of the most nightmarish experience ever!!! Leg cramps, chills non stop, could not be touched, felt roots of every piece of my hair, extremely sensitive to light, sound, touch, feel, etc... be very careful if u choose this path bc any adjustment in dosage will affect u greatly.
Because the problem with chronic pain suffering is... you don't have time to be "jerked around" or questioned. Its serious. The narcotic route definitely helps but unfortunately still leaves you, un-alleviated. Therefore, you still are addressing the pain factor with the docs and they are just waiting to yank you off of what they put you on, because they have restraints, fears of what whomever may think or get on their cases..so even if they start you on it, they are hoping it's short lived and always throwing a million different procedures, appointments at you, to do right when they say to do it.. to keep records (for their end) of why they prescribe you the meds.. even if you have 10 years documentation of MRI's, Nerve conduction studies, Diagnosis', Epidurals, trigger Point injections, many med trials, other meds taken daily along with the pain meds, etc..
24 Sep 2011
Cymbalta and its side effects it had upon my wife was disastrous. There was a rapid down ward spiral into a hallucinogenic world. I had a hard time controlling her actions and finally got her to stop taking it. She ended up in the hospital for lots of reactions that were not real. Cat scans, blood tests
psychological testing, lasted for three days until she returned to her self skinnier, beaten down, wore out. She replaced Cymbalta with Lyrica, which seems to be working for her. I personally have just used Lyrica with very little effect either way. I use morphine sulfate, 30 mg; 4 times per day.
And while it does provide some unwanted side effects, it tends to take away most pain for me.
10 Nov 2011
Yes, I think any untried path is worth a try when dealing with pain--in my case extreme migraines 24/7 after a major stroke. An anti-depressant helped me. There are many other treatments as well, e.g. nerve block injections and Botox injections which have helped me a lot. The first dose of the Botox didn't help me at all. But the second time when the doctor increased the dose to 200 units did help me. Also an herbal medicine called Petadolex which is butterburr root has helped me. And also a transdermal gel stops most of my headaches from becoming worse which saves me from the heavy pain killers.
Good luck with it all.
12 Nov 2011
I'm sorry DzooBaby, but I didn't have the time nor the stomach to read every response to your question. The answer to your question is YES, several anti-depressants are prescribed concomitantly with pain meds, which seem to help amplify their effects. There are several reasons for this, but you didn't ask for a dissertation, so I won't bore you with one. A very good antidepressant to take for this reason is Wellbutrin, which now comes in generic form, so it's not going to break the bank. (I'm sorry, I don't know if you have insurance or not, but it is covered).
Be CAREFUL with antidepressants, I've tried MANY & the majority of them either didn't work, or actually made me sicker or caused NEW problems, which none of us need! Cymbalta SUCKS & made me crazy, by the way. Gabapentin is NOT an antidepressant, it is a drug for nerve damage/disorders.
30 Dec 2011
I have the hand edema, and now wonder from you question if that might be a contributing factor. They hurt! I tried Tramadol for pain, but he prescribed such a lose dose. The neurolgoist that is. Even my primary doctor said it was like a drop in the ocean. He used more colorful words, but same effect. Anyway, the Tramadol around 150mg helps. I also have Ativan for anxiety. They all contribute. Cymbalta didn't touch my pain and discomfort. Not sure what I'd suggest. I've tried the Gabapentin/Neurontin routine, with vague results. Good luck. I'd like to know if/when you find help. Guess I'm not the one to do that, but perhaps we can both benefit. :) ~MJ~
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Similar questions
Restless Legs Syndrome - I have severe restless leg syndrome. I am on requip for about a month and?
... no relief. I also take lyrica, amrix and soma for my back (3 herniated disks). One leg will start and then go away and then the other leg starts. ...
Is gabapentin effective in treating Restless Leg Syndrome?
Periodic Limb Movement Disorder - good for restless legs. I have restless leg syndrom and must take 5-6 requip per day to relieve. is gabapentin 100 ...
Fibromyalgia - Do you have type of seizure(jerking of your body) when going to sleep?
and eventually will you get lupus from fibro. I am on lyrica, requip,
Can gabapentin cause you to jerk? I have been on it for a few years and this just started. Take?
... 800mg. 2x a day. I also take oxycodone 30mg. 3x a day, cymbalta 60mg., I have a plate in my neck on 4&5, dupreygens, ledderhosen, sjodgrens, ...
Can you discontinue sertraline (Zoloft) and immediately start taking Cymbalta or Lyrica?
I have a 95 yr old mother with severe knee osteoarthritis and restless leg syndrome and is in the early stages of dementia. She is currently on ...

Isn't this the craps? Doctors are to do no harm, but in withholding a solution
to your pain problem is violating this oath. I have a hard time getting the morphine that controls my constant pain, but I've found a doctor who will let me have as much as I can handle. The reason many of these good drugs were made illegal, was to catch the mafia of the '20's,'30's and early '40's for crimes other than what they were charge with. So good drugs were made illegal. Drugs do lead a society down the road to hell, if that society consumes lots of pain pills. But. . . . . .
Good thing most of normal society do not wish to be drugged up through the day. For a doctor that withholds medication makes him just as dishonest as the Congress of the United States. Just the pits. Congress does not know everything.
Gabapentin workds well for my facila neuropathic pain in conjuncture with acupuncture twice a week. I also take lorzepam for anxiety and when I am relaxed the pain lessens too.
I have heard that some of the old tricyclic ADs help for pain. I also take Traladik which is Ultram and it's a synthetic morphine.
Keep asking and it's trial and error. Good health to us all, P
Benzo's do nothing for pain, that is a farce.
First Amitriptyline and now Nortriptyline has lowered the intensity of the ?neuralgic pain I have endured for years. I started this med in August. I used to cry daily from the pain, douse myself in bengay type medicine of the highest strengths, and stay on a heating pad. These medicines have not cured me but have restored some pleasantry to my quality of life and I am less frail. I have been referred to a pain clinic after admitting that the norco didn't provide complete relief all day, kind of needed a mid day dose. I have structural injuries that I am going for my second back shot tomorrow. The pain doctor is doing zillions of tests to show that I in fact have fibromyalgia. I regret my care I received through the hospital I worked for in a major metro area because I was pulled aside for using both ice packs and a heating pad in my closed office working nights and was ultimately let go. I wish you the best and please let me know.
Expand this post...
I too am desparate for pain relief and have some decrease in pain by the fact that I am on disability at this time for mental reasons so they didn't pursue further my physical health. Steph
I would be careful asking for an antidepressant ssri. They are nasty
meds with tons of side effects. some permanent. Usually they will
destroy your sex life. Also they are hard to get off of with a
terrible withdrawal syndrome. It is not proven that they actually
work or do what they are supposed to do.
First I would research anti depressants (ssri) they don't vary that
much. Doctors are clueless about their significant and dangerous
side effects and withdrawal syndrome... they are really in denial
and the drug cos have been caught publishing only the positive
results.
They aren't what they are cracked up to be. I would stay away from
anti depressants unless you find one that is really needed for
your particular condition.