My Dr. just gave me the new RLS drug Horizant last week. He said everyone loves it and it doesn't even script Mirapex for his patients any longer. I took it last Fri for the 1st time and I slept great, but the next am I was very dizzy and sleepy, finally got over that in the early PM. Sat I took it again @ 5pm and by 10 I couldn't stand it, I was up all night but legs with all over the place!!! So I gave it another try on Sun @ 7pm and it was even worse, OMG! I thought this was going to be so much better than Mirapex, finally @ 2 am I took my Mirapex and was asleept with the hr. I really want to take the Horizant, thew mirapex much me put on weight and retain more water. Sounds crazy but its does. Help does anyone have input on this new drug and does it take a week or so to take effect. I was ready to pull out my hair!!
I called the Dr. but I won't know anything for a day or so. Thanks!
I have been taking Mirapex for restless legs for 5+ yrs. Can't go to sleep w/o it?
- Posted:
- 11 Oct 2011 by grammar
- Topics:
- mirapex, restless legs syndrome, sleep disorders, sleep, horizant
Added 11 Oct 2011:
Took it again last night and slept great - did get up after 6 hrs sleep but that was 4 am - no jumpy legs & very little dizziness. I think because I had a glass of wine around 4:30 pm might have made for a bad night before!
Responses (4)
11 Oct 2011
Hey grammar,
Horizant as you know is a realitively new medicine so don't believe there is alot of users out there yet to give you feed back. The symptoms you are describing are possible serious side effects of the Horizant and need to be addressed by the doctor right away. To read more about Horizant try the following:
http://www.drugs.com/horizant.html
Best wishes,
Laurie
29 Nov 2011
I took Horizant once (I normally take Mirapex) and it was a night from HELL. I didn't sleep all night and jerked so bad, I was miserable. I'll never try it again. Once was enough for me. The only reason I agreed to change from Mirapex is I am at what I think is the limit on dosage for RLS. Seeing my doc tomorrow.
i also took horizant once,, and that was the worse 10 hours that i had, i was up all night felt like i was in another world, blood pressure was high, so it didnt agree with me,,, had to take my mirapex within an hour of the horizant,, wont take
6 Mar 2012
I'm taking Horizant & Mirapex. The Horizant helps a lot and I was hoping to stop the Mirapex but my legs go CRAZY if I try. I was able to cut my Mirapex in half but I can't go without it. This is much worse than just restless legs.
My schedule is Horizant at 4:45 and Mirapex (.125) at 6:15. I'm in bed then around 8:00 as I get up at 4:00 am.
Mirapex worked fine for about 8 weeks and then the 'rebound effect' started and I was hoping to go to something else but it takes a while to ween away from it. I would suggest SLOWLY reducing the Mirapex while keeping steady with the Horizant. My doctor says that Mirapex is not addicting but my legs have never felt like they do when I don't take it. VERY uncomfortable. Once I'm able to get away from Mirapex I'll never go back - nor would I ever recommend it. I was better off before ever starting on it.
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How long did it take to get used to the Horizant?
It has really helped the RLS but sleepy during the day.

I've been on horizant for about a month now. When I first went off the Mirapex, I had terrible nights. Withdrawal I believe. I need to take two horizant each night. In my circumstances It took a week or so to calm down my legs after the withdrawal. Everyones different.