I got Synvisc One injection from Dr. on April 21, 2011. He gave it like an ordinary injection in the knee and said Synvisc One will go in the knee joint on its own. I feel injection is not in the joint, I have severe unbearable pain in the knee, very stiff burning pain, cannot walk and find difficult to drive . At times I feel like throwing up. After I complained to Dr. O\Brian he told me that he cannot do anything for me and go to family Dr.. Family doctor knows little about this injection I don’t know what to do. I don’t know what kind of side effects this material has and how long this will go on. Please help. Called Genzyme many time. No help.
28 May 2011
I have read some info about this inj. I have copied & pasted below, hope this helps you:
In clinical trials, the most commonly reported adverse events were transient local pain, swelling, and/or effusion in the injected knee. In some cases, these symptoms have been extensive. Other side effects such as rash have been reported rarely. Synvisc is contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the knee. Healthcare practitioners should exercise caution when using Synvisc in patients allergic to avian proteins, feathers, or egg products; who have evidence of venous or lymphatic stasis in the leg to be treated; or who have severe inflammation in the knee joint to be treated. Patients should be advised to avoid strenuous or prolonged weight-bearing activities after treatment. Strict adherence to aseptic technique must be followed to avoid joint infection. The safety and effectiveness of Synvisc in children and in pregnant or lactating women have not been established. It is unknown whether Synvisc is excreted in human milk.
One of the world's leading biotechnology companies, Genzyme is dedicated to making a major positive impact on the lives of people with serious diseases. Since 1981, the company has grown from a small start-up to a diversified enterprise with more than 9,000 employees in locations spanning the globe and 2006 revenues of $3.2 billion. Genzyme has been selected by FORTUNE as one of the "100 Best Companies to Work for" in the United States.
With many established products and services helping patients in nearly 90 countries, Genzyme is a leader in the effort to develop and apply the most advanced technologies in the life sciences. The company's products and services are focused on rare inherited disorders, kidney disease, orthopaedics, cancer, transplant, and diagnostic testing. Genzyme's commitment to innovation continues today with a substantial development program focused on these fields, as well as immune disease, infectious disease, and other areas of unmet medical need.
This press release contains forward-looking statements, including statements about: whether and when Synvisc-One obtains marketing approval in the US, whether a single-injection regimen of Synvisc will reduce costs and burden, and provide additional options for physicians, and the timing of a regulatory filing for Synvisc-One in Europe. These statements are subject to risks and uncertainties that could cause actual results to differ materially from those projected in these forward-looking statements. These risks and uncertainties include, among others: extent to which the US Food and Drug Administration determines that Synvisc-One can appropriately be approved for marketing in the US, the extent to which the government and private insurers recognize the benefits of Synvisc-One and maintain or otherwise implement reimbursement policies that reflect these benefits, our ability to prepare the necessary regulatory filing for Europe in a timely fashion; and the risks and uncertainties described in reports filed by Genzyme with the U.S. Securities and Exchange Commission, including without limitation the factors discussed under the caption "Risk Factors" in Genzyme's Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2007. We caution investors not to place undue reliance on the forward-looking statements contained in this press release. These statements speak only as of the date of this press release, and we undertake no obligation to update or revise the statements.
Genzyme and Synvisc are registered trademarks and Synvisc-One is a trademark of Genzyme Corporation. All rights reserved.
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Good luck to you...
28 May 2011
It has been over a month since your injection - I would be very concerned. If your orthopedic Dr that gave you the injection does not respond to you - I would seek out a second opinion with another orthopedic Dr. It is not likely that one doctor will speak against another but hopefully they will help to figure out what the problem is. I would not just let it go. If the area is warm and inflamed and/or you start running a fever get to a doctor or emergency room right away. It could be infected, although if it was that probably would have shown up by now. Anyway, you have to do something and a second opinion is a good place to start.
8 Mar 2012
Hi, I had my first injection out of 3 yesterday. First time getting it. Was very nervous, and told Dr i was. He said to just relax or he cant put the needle in. He had to put it in 2 times, because i wasnt relaxed enough. Finally i was relaxed enough and he put it in. It felt very werid, and i felt the stuff going into my knee cap. It didnt hurt as he put some freezing in. After it was done, i walked out, and it felt werid. about 2 hours later i started to feel alittle bit of pain. I kept walking on my knee to help with the pain. I had to take 2 tylonals for the pain. Laying in bed made my knee feel better. Today it feels better then it did yesterday. 2 more injections to go!! I hope you feel better soon.
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