how long will it stay in my system
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How long does Methadone stay in your system?
5 Mar 2010
Methadone has a very variable elimination half life (please see below). It takes 5.5 elimination half life's for a medicine to be eliminated from ones system.
If we use the maximum elimination half life of 59 hours then methadone should be cleared in 324.5 hours (5.5 x 59 hours).
(Excretion – The elimination of Methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Published reports indicate that after multiple dose administration the terminal half-life (T1/2) was highly variable and ranged between 8 to 59 hours in different studies. Since Methadone is lipophilic, it has been known to persist in the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of Methadone action despite low plasma concentrations.)
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