How long before chloroquine takes effect?

11 Nov 2010

Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract following oral administration and peak plasma concentrations of the drug are generally attained within 1-2 hours. Chloroquine is widely distributed into body tissues such as the eyes, heart, kidneys, liver and lungs, where retention is prolonged. Concentrations are two to five times higher in erythrocytes than in plasma. Very low concentrations are found in intestinal wall. Chloroquine crosses the placenta and is distributed into breast milk.

Approximately 55% of the drug in the plasma is bound to plasma proteins. It is metabolised in the liver to active de-ethylated metabolites. Principal metabolite is desethylchloroquine. The plasma half life of chloroquine in healthy individuals is generally reported to be 72-120 hours.

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