13 Mar 2011
Single dose studies with Glyburide Tablets, in normal subjects demonstrate significant absorption of glyburide within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Mean serum levels of glyburide, as reflected by areas under the serum concentration-time curve, increase in proportion to corresponding increases in dose. Multiple dose studies with Glyburide Tablets, in diabetic patients demonstrate drug level concentration-time curves similar to single dose studies, indicating no buildup of drug in tissue depots. The decrease of glyburide in the serum of normal healthy individuals is biphasic; the terminal half-life is about 10 hours. In single dose studies in fasting normal subjects, the degree and duration of blood glucose lowering is proportional to the dose administered and to the area under the drug level concentration-time curve.
The blood glucose lowering effect persists for 24 hours following single morning doses in nonfasting diabetic patients. Under conditions of repeated administration in diabetic patients, however, there is no reliable correlation between blood drug levels and fasting blood glucose levels. A one year study of diabetic patients treated with Glybruide Tablets, showed no reliable correlation between administered dose and serum drug level.
- Glyburide Information for Consumers
- Glyburide Information for Healthcare Professionals (includes dosage details)
- Side Effects of Glyburide (detailed)
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Diabetes, Type 2 - I have taken metformin on and off and each time I have severe bowel disturbances?
... My bs runs about 140 with glyburide alone. I try to take metformin to get my bs closer to 100. Is there any other me I can take that will NOT ...
4 answers • 13 Oct 2009
I was on 5mg glyburide 2xdaily and 500mg metformin 2-3x daily. My A1c was 8-8.5. My Dr. added 100 januvia. Afterwards my sugar were much lower so I ...
1 answer • 2 Jul 2010
Glyburide is a sulfonylurea based medication.
1 answer • 22 Nov 2010
Do all type 2 diabetes meds have the same side affects?
1 answer • 25 Aug 2011