13 Mar 2011
Single dose studies with Glyburide Tablets, in normal subjects demonstrate significant absorption of glyburide within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Mean serum levels of glyburide, as reflected by areas under the serum concentration-time curve, increase in proportion to corresponding increases in dose. Multiple dose studies with Glyburide Tablets, in diabetic patients demonstrate drug level concentration-time curves similar to single dose studies, indicating no buildup of drug in tissue depots. The decrease of glyburide in the serum of normal healthy individuals is biphasic; the terminal half-life is about 10 hours. In single dose studies in fasting normal subjects, the degree and duration of blood glucose lowering is proportional to the dose administered and to the area under the drug level concentration-time curve.
The blood glucose lowering effect persists for 24 hours following single morning doses in nonfasting diabetic patients. Under conditions of repeated administration in diabetic patients, however, there is no reliable correlation between blood drug levels and fasting blood glucose levels. A one year study of diabetic patients treated with Glybruide Tablets, showed no reliable correlation between administered dose and serum drug level.
- Glyburide Information for Consumers
- Glyburide Information for Healthcare Professionals (includes dosage details)
- Side Effects of Glyburide (detailed)
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I was on 5mg glyburide 2xdaily and 500mg metformin 2-3x daily. My A1c was 8-8.5. My Dr. added 100 januvia. Afterwards my sugar were much lower so I ...
1 answer • 2 Jul 2010
Diabetes 2. I was switched to glyburide 2 years ago. This is the only medication that I am on. Over the last couple of years, I've developed ...
1 answer • 4 Jul 2010
I have gone thru drug therapy for the Hep C and have a zero viral load, no detection of it, but I am still considered to have a liver disease. Can ...
1 answer • 14 Aug 2010
Do all type 2 diabetes meds have the same side affects?
1 answer • 25 Aug 2011
New to the site...very new to gestational diabetes. Dr. wants me to take glyburide. Only because of?
... my fasting #s. all other #s are exceptional. Any input would be appreciated. Who has taken it, what are your opinions, please?
0 answers • 22 Sep 2015