meanmozI take my dilantin regularly but then continue with seizures and when a dilantin level is done it is below 10. My blood glucose has been elevated 6 out of the 13 times done.
How does an elevated blood glucose lower the dilantin level in blood?
- Posted:
- 5 Oct 2010 by meanmoz
- Topics:
- dilantin, seizures, glucose, blood disorders
Details:
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Answers (1)
Marvell3 Nov 2010
This effect is a known side effect of Dilantin.
The presence of diabetes mellitus (both types I and II) has been associated with alterations in the pharmacokinetic disposition of phenytoin. Decreases in plasma protein binding, Vmax and Vmax/Km have been reported. (Km is the serum concentration at which 50% saturation occurs and Vmax is the maximum rate of metabolism.) As a result, lower steady-state concentration of phenytoin may occur in patients with diabetes mellitus.
I hope this explains it okay. I don't know how to put it simply ... but if you don't understand please add a comment and I'll try to make you understand.
Or please discuss with your doctor.
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