Last week my rheumatologist prescribed Tramadol 50mg (Ultram) to take 3 times daily as needed for pain due to RA and osteoarthritis in my knees. I tried taking it after a meal and at bedtime hoping I wouldn't feel the nausea while I was sleeping, but it (the nausea) just kept me awake most of the night. Does it take time to get in my system and the feeling of nausea will eventually go away? Any suggestions would be appreciated?