How celecoxib distrub G.I?

Celecoxib is a non-steroidal anti-inflammatory drug, specifically a COX-2 inhibitor.

NSAIDs are used for the relief of pain and inflammation in rheumatoid arthritis. However, these do not change the course of disease or prevent joint destruction.

Although NSAIDs differ in structure they all have similar antipyretic, anti-inflammatory and analgesic properties. However, there can be considerable variation in individual patient response and tolerance to different NSAIDs.

Expand this post...

NSAIDs primarily work by inhibiting arachidonate cyclo-oxygenase (COX enzyme) and thus inhibits the production of prostaglandins and thromboxanes. There are two types of COX enzymes, COX-1 and COX-2. COX-1 is expressed in most tissues, including platelets. COX-2 is induced in inflammatory cells when they are activated and the primary inflammatory cytokines (interleukin-1 and tumor necrosis factor alpha). COX-2 enzyme is responsible for production of mediators of inflammation. Most NSAIDs are inhibitors of both isoenzymes. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

The most common side effect of NSAIDs is gastrointestinal irritation, which can even lead to gastrointestinal ulceration or bleeding. NSAIDs must be taken with food to prevent or minimize these side effects, but this does not decrease the risk of bleeding. Taking a combination of NSAIDs, or NSAIDs and aspirin together increases the risk of stomach ulcers or gastrointestinal bleeding. Long term use can also cause possible heart problems.

Cycloxygenase inhibitors block an inflammation promoting enzyme called COX-2. This class of drugs was initially believed to work as well as traditional NSAIDs, but with fewer stomach problems.

Hope this helps.

http://www.drugs.com/rheumatoid-arthritis.html