"Under one year of age, current available data are limited but suggest that the half-life at birth may be as long as 29 hours, decreasing to 11-12 hours by three months of age and 6 hours by one year of age. The pharmacokinetics in hydropic infants have not been studied, but case reports suggest prolonged elimination. In children aged 1 year to 12 years the half-life is approximately 8 hours. In adolescents (age 12 to 15) the plasma elimination half-life is approximately 11-12 hours. Since milk may inhibit absorption in infants, a reduction in Flecainide dosage should be considered when milk is removed from the diet (e.g., gastroenteritis, weaning). Plasma trough Flecainide levels should be monitored during major changes in dietary milk intake."
http://www.drugs.com/pro/flecainide.html
The last is the best... I went to google, typed in the word google scholar.
Clicked that and typed in flecainide for atrial fibrillation in children
I found that this medication was a first line of treatment. So it sounds like you are on the right track.
"Most patients in the younger group (17 of 22) received digoxin and/or a beta-blocker as the first line of medical therapy. Additional first line medications in the younger patients included flecainide (3 patients), amiodarone (1 patient), and a combination of digoxin and sotalol (1 patient). Responders to first line therapy included eight of the 17 who were treated with digoxin and/or a beta-blocker, as well as two of the three who were on flecainide. The patients started on sotalol or amiodarone as first line therapy did not achieve control until additional medications were added.
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Table 1 Medical Management in Children <3 Years of Age (n = 22)
Drug toxicity occurred in two patients in the younger group. One child who was receiving flecainide developed a new right bundle branch block with an accelerated ventricular rhythm, and a second child had a toxic flecainide level (flecainide level 1,700 ng/dl on 120 mg/m2/day) without evidence of clinical toxicity.
Spontaneous resolution
Excluding four patients in the younger group who were still on drug therapy, 14 of the possible 18 (78%) patients had complete resolution. The mean duration of therapy in those patients whose AET did spontaneously resolve was 12 ± 7 months.
RFA
Only two of the 22 patients in the younger group who were diagnosed at less than three years of age underwent RFA; both were successful in the short term. Their ages at the time of RFA were six months and nine years. The six-month-old underwent RFA due to a progressive cardiomyopathy despite medical therapy with amiodarone. The ablation was successful with an early recurrence of AET. The AET focus was modified by the RFA as it was more easily controlled with medication after ablation, followed by resolution once antiarrhythmics were discontinued. The older of these two patients had been on multiple antiarrhythmic combinations and ultimately underwent a successful RFA secondary to family preference.
Surgical intervention
None of the patients in the younger group required surgical intervention.
Cardiomyopathy
All three of the patients who presented with myocardial dysfunction in the younger group had improved function after intervention. The two patients who presented with mild-to-moderate myocardial dysfunction both had improved function while on antiarrhythmic therapy. The single patient in the younger group with a severe cardiomyopathy was discussed above. He was tried on multiple medical regimens without success and ultimately underwent RFA at six months of age. Due to recurrence of AET after RFA, he was placed on, and responded to, amiodarone with normalization of function.
Group 2. Patient profile
There were 46 patients diagnosed with AET at 3 years of age (median, 10 years; range, 3 to 18 years). The mean follow-up time was 20 months (range, 1 week to 120 months). There were three patients in the older group who were lost to follow-up.
Presentation
Common reasons for referral included irregular heart rate (16 patients), tachycardia (13 patients), palpitations (11 patients), and for other reasons (6 patients). At presentation, echocardiograms were performed in 40 of 46 (87%) in the older group. There was echocardiographic evidence of decreased function in eight patients with a severe cardiomyopathy resulting in referral for transplant evaluation in two patients (ejection fractions by Simpson's biplane method of 16% and 20%). The single anatomic abnormality in the older group consisted of a quadricuspid aortic valve that was neither stenotic nor regurgitant.
Antiarrhythmic therapy
Antiarrhythmic medications were used as the initial therapy in 35 of 46 (76%) of the older patients, with a median of two drugs (range, 1 to 5) per patient. Similar to the younger group, drug doses were typically increased to achieve clinical control or until measured serum levels were therapeutic. Control of AET while on antiarrhythmic therapy was achieved in only 13 of 35 (37%) of the older children. Drugs used in the older group and their effects are detailed in Table 2. As with the younger group, most patients (30 of 35) in the older group were initially started on digoxin and/or beta-blocker therapy. Additional first line medications included procainamide (1 patient), ethmozine (1 patient), flecainide (1 patient), and a combination of digoxin and quinidine (2 patients). There were 13 patients in the older group who achieved control, nine of whom received digoxin and/or beta-blocker therapy. Additional medications used to achieve control in the older group included ethmozine (1 patient), flecainide with a beta blocker (1 patient), and digoxin with flecainide (2 patients). There were no toxic side effects in the older group. "
http://content.onlinejacc.org/cgi/content/full/43/3/438
I will keep your family in my prayers and know that there is a rainbow after the storm. Just look for it.
Your research is incredible. Your information is very detailed and I am sure this will help Mom and Dad alot and hopefully give them some insight on what questions they may have for their Doctors. You got my thumbs up. Barb
My daughter is 8 wks old and has had at the least 7 svt episodes (high heart rates as high as 360) in the last 7 wks they have had her on propanolol since she was 5 days old and now have her on that as well as flecanide for the past couple of wks. before letting her leave the hospital they did a echo on her and said the combo of meds. are doing their jobs propanolol is keeping her heart rate low and flecanide is "paralyzing" her wpw (xtra pathway)... I think they are doing the job, but want to learn the pros and cons of her being on these meds... wish you luck