... off work on short term disability. I was already taking Zoloft 50mg, but my doc upped that to 200mg and just added 12.5mg of Seroquel to boost the Zoloft and help with sleep. Anybody used Seroquel in low doses as an add-on to their antidepressant? How did it work? How long did it take for you to get maximum benefit? Any input at all would be appreciated. Thank you