... and am taking Tamoxifen for a couple of weeks. Just told there can be a drug interaction between Tamoxifen and Zoloft (possibly diminishing effect of Tamoxifen). I would like to continue to use Tamoxifen to see if it works for me (have already had other drug therapy over the last 5 years) and want to know if anyone is familiar with this situation and changed their zoloft type of med for another.antidepressant in a different category with good results. Thanks.