I have been on Cymbalta for several years after being diagnosed with Rheumatoid Arthritis and Fybromyalga after my second child. I have gained so much weight and am the largest I have ever been. I also have extreme fatigue in which I go through periods of what I call "the blahs". I feel as though I have the flu in a sense, no motivation, very sleepy, feel sick when I get up that kind of thing. My doctor is wanting me to wean off of the Cymbalta and to start taking Pristique. Although the Cymbalta is effective, I really think that is the cause of my weight gain. Trying to figure out if Pristique is as effective but will help some of these other conditions.