Been on Xeloda 1 1/2 years' now - major side effect is hand and foot syndrome. I use Bag Balm esp at night and try to lubricate during day but difficult. Wear gloves in the house to fold laundry and other chores that make my hands feel even more dry. For about a month now my right leg feels like it is asleep (from right foot to the knee only). Thigh is fine. It makes me wonder if the blood is circulating and will it eventually go dead and need amputation? That is my main concern. I hope someone can answer this.