Prazosin was prescribed for my PTSD nightmares. Immediately, I began to experience severe pain and swelling in both knees, so we cut back from 2mg to 1 mg. The problem continued so we stopped altogether. It's been several months and I'm still having the knee problems. I've been with this doctor for over 10 years so he knows my medical history and he still feels uncomfortable associating my knee problems (which I didn't have prior to this medication) with Prazosin. I've gone from being pretty athletic to barely able to climb stairs. Any advice?
Has anyone experienced any joint problems with Prazosin?
- Posted:
- 10 May 2011 by Ufu
- Topics:
- post traumatic stress disorder, nightmares, pain, prazosin, swelling, knee
Details:
Responses (2)
11 May 2011
I have been taking Prazosin for almost a year. I started with 1mg and ultimately increased to 3 mg. The doc prescribed it for severe diaphoresis
secondary to my pain medications. I have ongoing joint problems, including
rheumatoid arthritis but have had no additional swelling. I also have knee
problems but they have not increased as a result of the Prazosin. I am guessing you feel fairly good about your doc because you have been with
him for so long. There are so many disorders that appear to be secondary
to a med but just may be something else cropping up. I'll check with my doc
who prescribes the Prazosin at my next appointment to see if he has any
knowledge of a reaction such as your to Prazosin. Good Luck...
LaurieShay11 May 2011
Hey Ufu,
After reviweing the literature for Prazosin, I found the following:
Musculoskeletal side effects including rare cases of musculoskeletal complaints and acute febrile polyarthritis have been associated with the use of prazosin. The suspected mechanism is immunologic hypersensitivity.
It may be that your body reacted to this medication by producing an immune repsonse as mentioned above. The following article discusses this response to prazosin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690399/
Make a copy of this article and take to your doctor. It may well explain what has happened to you.
Best wishes,
Laurie
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