... So does that mean all acids such as Vinegar are equally bad?
27 Oct 2011
No, vinegar (or other acids generally) has no known negative effects when taken with lisinopril and lovastatin.
Grapefruit juice doesn't affect lisinopril, it just has an interaction when taken with lovastatin.
In small studies, the consumption of large amounts of grapefruit juice was associated with significantly increased plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Similar results but to a lesser degree were reported for atorvastatin. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Increased risk of musculoskeletal toxicity (myopathy with grossly elevated creatine kinase and rhabdomyolysis with or without acute renal failure secondary to myoglobinuria) has been associated with high levels of HMG-CoA reductase inhibitory activity in plasma.
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