Is it safe to drink grapefruit juice with oxycodone (or any opiates for that matter)? I read somewhere that if you drink grapefruit juice while taking OC that it will stop it from being metabolized in your liver, hence making it last longer in ur system and lower your tolerance to how much you have to take. Basically what i am saying is that Grapefruit juice will enhance the effects of Oxycodone? Is this statment true to any degree. please give me some info or personal beliefs im open to all opinions