Fosamax - What is the connection between this drug and cancer of the oesophagus and deterioration of

I don't know about cancer of the esophagus but it can cause esophageal cancers.

Postmarketing experience has reported esophagitis, esophageal erosions, esophageal ulcers, rarely esophageal stricture or perforation and oropharyngeal ulceration.

The combination of alendronate and naproxen has been reported as synergistic for development of gastric ulcers.

Gastrointestinal side effects have included abdominal pain, nausea, dyspepsia, constipation, diarrhea, and flatulence. Regurgitation, esophageal ulcer, vomiting, dysphagia, abdominal distention, and gastritis also have occurred. Rarely, taste perversion has been reported. The frequency of adverse effects increased with higher dosages.

Several cases of ulcerative esophagitis have been reported in patients receiving alendronate. Patients with preexisting esophageal disorders and those who take alendronate with little or no water and lie down immediately following ingestion may be at an increased risk.

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AND yes, it can cause you to develop bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

http://www.drugs.com/sfx/fosamax-side-effects.html

http://www.drugs.com/fosamax.html