For years I was told I had major depression and I've tried so many antidepressants I can't even recall all of them. I've been taking 300 mg. wellbutrin for a few months now and not feeling much better. I was recently dx with bipolar 2. Five days ago I started taking 25 mg. of lamictal. (along with the wellbutrin) I take it at night because it makes me drowsy. I fall asleep better but I have a harder time getting up in the morning. Overall I'm feeling very depressed still. I'm wondering if I'm having a normal reaction to lamictal and how long have some had to be on it to feel improvement. I've read so many reviews where people said they felt improvement right away
9 Jul 2012
I took this once back in 1999. I developed an itchy rash once I started it and was told that it was rare to get that, but I guess I was the one. It might be possible the dose is too high for you. I was diagnosed with bipolar 2 in 1999 myself and after the lamictal didn't work I started depakote and I was taking prozac as well. In 2001 I decided I wanted to try to get pregnant, so I stopped the depakote cold turkey, and I tell you that was the best thing I ever did. That first week after stopping it I felt the best I had ever felt. I stopped the prozac shortly after cold turkey as well. I will never take depakote again. I mainly stay depressed, and only get manic episodes during severe life tragedies such as a divorce which I was going through when I was diagnosed as bipolar. I am taking wellbutrin now after stopping zoloft for anxiety and have not noticed a difference in how I feel. I still feel like crap. I also have anemia and possible thyroid issues so I don't know if that is why or what. I wish you all the best with the lamictal.
18 Jul 2013
Yes, it's normal. My dx is actually Generalized Anxiety Disorder, I was misprescribed and am actually withdrawing from it with my dr's guidance. But when my previous psychiatrist put me on it, I do remember not feeling well on week one every time he built up the dose. By week two, my body had gotten used to the new dosage. I must add that this drug has strong withdrawal side effects, it is NOT an antidepressant, but it is used as a mood stabilizer in bipolar disorders. For more info, google "Lamictal withdrawal" and consider talking to ur doctor about trying a similar mood stabilizer. As far as antidepressants... Have you tried Paxil? Best of luck, Mari.
10 Jul 2012
Hi! I've been on lamictol for 4yrs & I think since it dnt have any side effects people may think it dnt work ! Your on a very low dose you have to build up 25mg didn't work for me either. I'm now on 300mg & it helps control my moods & I'm able to take it during the day ! I have noticed some hair loss & after researching I found this to be a side effect from this medicine ! But hang in there give it a chance I think ull like it gud luck :)
17 Apr 2015
Your post is obviously some time ago. How are you feeling now? What is your current dosage of Lamictal? I have fought depression and anxiety for many years. I have tried many anti-depressants. I was also diagnosed with obsessive-compulsive disorder. I have been on a regimen which includes Paxil and Wellbutrin XL (50mg/300mg, respectively). This dosage had remained constant for approximately one year. While it helped a bit, the addition of Lamictal at this point in time seems to have made a world of difference. I have only been on it for four (4) days at the starting dosage of 25mg. After day 2 I felt so much improved and continue to do so. No side effects etc. Depression has lifted. I have reduced the paxil/wellbutrin combo down to 37.5mg/150mg. I will titrate to 50mg of Lamictal next week. Morning dosage. You must understand, everyone's physiological make up is different. Based on this you will have different results and different synergistic effects with the drugs you are currently on. Lamictal has seemed to be very effective at this early point in time. Since it is so early I continue to approach it cautiously but feel I am headed in the right direction. I hope this helps.
1 Apr 2015
I just started Lamictal 8 days ago at 25 mg. Some weird side affects first three days, then more hours of the day I think I was feeling better. I am not sure if it was due to the sunshine.
Yesterday I started the tiltrating up. I am afraid of it. I felt a little agitated yesterday, and kind of up an down. I am supposed to take 25mg in the morning and 25 mg at night.
I see my psychiatrist today to see what is next for me.
I have low-lying depressing. Severe anxiety most days. I do not have any manic episodes.
Taking Ativan for morning anxiety.
I hope he prescribes me more. Ativan helps me get to work, it seems.
23 Jan 2013
I didn't notice any improvement until I got to 100 mg. I am now on 300 mg and I have been on this med for many years. I recall how I was before it and it wasn't good. I don't think I ever had any side effects, but at times my vision gets blurry. I take a bit of it in the morning and some at bedtime. For me, Lamictal actually wakes me up. If I take it all at bedtime, I have trouble sleeping... amazing how we all react to meds differently. My best to you.
22 Jan 2013
It can take up to eight weeks to feel the full effects of the drug. Usually four weeks is a good measuring stick as to when you should start feeling the effects. Some people feel effects in a week or less, while others take much longer. Stick with it. Bipolar II is a tough illness but Lamotrigine is one of the safest and most effective ways of treating it. In time your quality of life will improve greatly.
Also, 25 mg is the starting dose for almost everyone, as any higher dose can have some very serious side effects if you're just starting out. Most people end up at a dose of 100 mg or higher. Again, be patient and remember you have the rest of your life to get better, but only a few days to get much, much worse if you rush into things.
I wish you the best of luck, health, and wellness. God bless :)
9 Jul 2012
Hi Kate. I've been taking Lamictal (generic form) for approx a year now. Initially, I didn't feel any different, however, I've been on 300mg for about six months now and its helped me regain my life. I know its a bit more than the therapeutic dose, however, the mood swings have disappeared. I am also on 300mg of Wellbutrin XL, 100mg of Zoloft, and 60mg of Ritalin. It really sucks to be on so much medication to make me feel normal, but it works. My diagnosis is A.D.D., P.T.S.D. and depression. Good luck!
17 Jul 2012
Kate5, all the answers above are good ones, you have to give lamictal/lamotragine time to start working. It's frustrating that they have to start at real low doses and increase slowly, due to some scary side effects. I too take Wellbutrin (450mg). I started lamotragine about a year ago and after about 6 weeks I started feeling much better than I have for decades. After I got to 200 mg, I was a new man, not depressed any more with tons of energy. I have since gone to 300 mg which seems to be my maintenance dose. My depression started around 1980 and since then I've tried many anit-depressants, nothing even comes close to the combination of wellbutrin and lamotragine. I think you are on the right track, give it time. Ironically I have never been diagnosed as bipolar, never had a manic attack, no seizures, my therapist considers lamictal to be a mood stabilizer and it has done that.
22 Jan 2013
Kate5, I just want to say i agree with the others, and encourage you to hang in there and wait for the dosage to be upped. I'm not going to repeat what everybody else has, but it took me a while before my stubborne self would take anything. I was a complete total alcoholic mess too. I quit drinking about 6 yrs ago, and started on an antidepressant. I will be honest with you, I seriously dont think I gave the medicine's I was prescribed time to work, and got discouraged and said forget this, and here we get on something else. I finally realized, it was me having the problem, not the medicines, so I gave one a chance, and after a bit I felt my depression getting better, but I'm telling you, I was started at a low dose too, but now, I feel great. I still have life issues I have to deal with. Severe dissapointment's, and normal things people go through, but I handle it soo much better now. Oh, I wish you tons of luck and please be patient. Many blessings to you, Ruthie
17 Jul 2015
I am also on Wellbutrin XR 300mg and have been for years. I had a genetic assay report done that indicated I might benefit from one mood stabilizer in particular, Lamictal, and also validated why 25+ years of different antidepressants hadn't worked (they were on the "danger" list as being either high or slow metabolizers).
I haven't been diagnosed with BP, but certainly MDD without psychosis, and as this has developed, we have realized that I may have a "non-specific" mood disorder, but it's just too difficult to put a label on it right now.
In my experience, the very first 24 hours, I had an IMMEDIATE positive reaction to 25 mg Lamotrigine. Uplifted sense of self, interest in talking with others, participating in activities outdoors, etc. this continued for approximately 4-5 days then it's like it drifted away like a wispy cloud I couldn't grasp hold of. I did have terrible insomnia, so I took it at 5 PM (no work responsibilities, early enough not to ruin my night). My Doc said not to worry, that I was basically on a pediatric dose, and my positive reaction was a good sign, as well as an indication that it was clicking with my genes like we had hoped (if you buy into that science).
We moved to 50, then 100. I realized that I was improving, but it was as though I would go through a dip or valley I would have to adjust to, whenever I would have a dose change. Definitely positive benefits, though, so we've been working our way up to a sweet spot, wherever that may be. I hear the therapeutic dose is 200mg, but we'll let my body be the guide.
I keep a daily "mood disorder checklist" that charts my energy, anxiety, self-esteem, hours of sleep, whether I'm sick, menstruating, etc. - the chart is huge, but it is important for me to do this because I came from a place a few years ago where I didn't see a future for myself, so I need to take this very seriously.
I stumbled upon this thread today, actually, because I wondered if there were people out there who experience a bottoming-out or a lowering of potential when they move from short-acting to extended-release.
Most recently, my Doc switched me from 100mg to 100mg ER (i.e. XR) and said I should stay at 100 for a few weeks as just moving to extended-release would have a net-effect of a dosage increase.
All I know is that I'm 8 days in, and I've had a flat affect, an increase in anxiety, and a more rapid social awkwardness - possibly to the point of over-sharing. I'm trying to connect with people the way I have been, in the same avid fashion I have been in the months since I've started Lamictal, and I get a sense that people want our conversation to end, and I feel like an unbalanced creep.
It has helped me to see that some do dip down before leveling out. I would be really interested to see any follow up posts since this thread is so old. :) I hope everyone is doing well. Kate, how are you faring these days?
11 Jul 2012
Please be patient Kate,
I have Bipolar 1 and tend to suffer mainly the from the depressive side of the disorder. I have been on a combination of 400 mg of Welbutrin and 200 mg of Lamictal for over 6 yrs. and it works very well. The morning drowsiness will disapate as your body becomes accustom to the Lamictal. I have been on Welbutrin for a total of about 9 yrs. Prior to the Lamictal, I was on a combo of 600mg of Seroquel and 1000mg of Depakote along with a few other drugs which incl. the Welbutrin. This was like being comatosed! It was truly a Godsend when we realized that the Lamictal/Welbutrin combo was working. Being able to throw out all the other harsh anti-psychotropic drugs for the Lamictal was an added bonus. Stay strong through the process. I know it is a long haul, but we are all here to help one another get through it. Good luck and keep me posted as to your progress. Sincerely, T
9 Jul 2012
Hang in there Kate. You will find improvement over the next month as your dosage is increased to the theraputic dose of 200mg/day. Generally Lamictal is increased 25mgs every two weeks. You'll know it is working as you reach the right amount for you. Takes some patience, but this is a good medication for bipolar symptoms.
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