5 Aug 2009
There is a major drug interaction between Plavix (clopidogrel) and Nexium (esomeprazole).
GENERALLY AVOID: Coadministration with proton pump inhibitors (PPIs) may reduce the cardioprotective effects of clopidogrel. The proposed mechanism is PPI inhibition of the CYP450 2C19-mediated metabolic bioactivation of clopidogrel. This is consistent with studies that reported decreased effectiveness of clopidogrel in patients who have common genetic polymorphisms of CYP450 2C19 resulting in reduced or absent enzyme activity.
MANAGEMENT: Until further data are available, patients treated with clopidogrel should preferably avoid the use of proton pump inhibitors. H2-receptor antagonists or antacids should be considered whenever possible.
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3 answers • 7 Jun 2010
Sir, were you taking plavix before the Heart attacks? Did you have stent placement prior to by pass surgery? How long if at all were you previously ...
2 answers • 2 Aug 2010
have taken several years after heart attack and multiple stent placement it has become toooo costly
1 answer • 6 Oct 2011