5 Aug 2009
There is a major drug interaction between Plavix (clopidogrel) and Nexium (esomeprazole).
GENERALLY AVOID: Coadministration with proton pump inhibitors (PPIs) may reduce the cardioprotective effects of clopidogrel. The proposed mechanism is PPI inhibition of the CYP450 2C19-mediated metabolic bioactivation of clopidogrel. This is consistent with studies that reported decreased effectiveness of clopidogrel in patients who have common genetic polymorphisms of CYP450 2C19 resulting in reduced or absent enzyme activity.
MANAGEMENT: Until further data are available, patients treated with clopidogrel should preferably avoid the use of proton pump inhibitors. H2-receptor antagonists or antacids should be considered whenever possible.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
... time I have many of the side affects and just want to quit using it. I have been on it for 3 months already and have had problems with the way i ...
1 answer • 13 Oct 2009
1 answer • 3 May 2010
3 answers • 7 Jun 2010
,doctor wants me to quit tacking plavix,saying research indicates plavix only usefull for a year or so,is this true and should i stop tacking it?
1 answer • 22 Jun 2010