Effect of rifampin on prothrombin and clotting time?

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2 Feb 2010

Of particular importance is a potential drug interaction that exists with Rifampicin and certain anticoagulants...

This from http://www.drugs.com/pro/rifampin-capsules.html
"... Rifampin has been observed to increase the requirements for anticoagulant drugs of the coumarin type. In patients receiving anticoagulants and rifampin concurrently, it is recommended that the prothrombin time be performed daily or as frequently as necessary to establish and maintain the required dose of anticoagulant."

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