I take 10 mg of Amlodipine once daily in the morning, I understand grapefruit and beta blockers do not "get along". But Amlodipine is a calcium channel blocker, so am I okay to eat grapefruit or should I avoid it?
23 May 2013
There is a minor interaction,meaning:
The consumption of grapefruit juice may slightly increase plasma concentrations of amlodipine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Data have been conflicting and the clinical significance is unknown. Monitoring for calcium channel blocker adverse effects (e.g., headache, hypotension, syncope, tachycardia, edema) is recommended.
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Always consult with your DR. or Pharmacist/Chemist.
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