In my experience I tapered down from methadone to 20mgs a day waited 72 hours until taking suboxone. I felt dope sick briefly then normal the rest of the day. 36 hours latter I took my prescription ambien, a whole 30mg's of it, it did barely anything like it normally does. Also the effect of taking benzo's has also weakened, it must be some sort of indirect blocking of other non-opoid receptors, whats the deal!!!