I have been on 60mg Cymbalta bid for several years. My bipolar 2/generalized anxiety disorder has been very well controled. Now my primary doctor wants to take me off of Cymbalta because I have sever restless legs and arms also known as Periodic limb movement symdrom. I want to know if Cymbalta is the cause of this before I let the doctor change my medication.
7 Feb 2010
Yes, Restless Leg Syndrome has been reported as a side-effect of Cymbalta.
"... Adverse reactions reported since market introduction that were temporally related to duloxetine therapy and not mentioned elsewhere in labeling include: anaphylactic reaction, aggression and anger (particularly early in treatment or after treatment discontinuation), angioneurotic edema, erythema multiforme, extrapyramidal disorder, glaucoma, gynecological bleeding, hallucinations, hyperglycemia, hypersensitivity, hypertensive crisis, muscle spasm, rash, restless legs syndrome, seizures upon treatment discontinuation, supraventricular arrhythmia, tinnitus (upon treatment discontinuation), trismus, and urticaria."
23 Jul 2013
It seems medicines like seroquil, depakote, Cymbalta and others that are blocking or changing the ways our nerves communicate or operate ... It seems like they are causing this epidemic of twitches and muscle restlessness. Like they are short circuiting us from the inside out.
27 Aug 2013
Yes! After taking my first dose of 30mg Cymbalta for treatment of nerve pain, I developed restless leg tremors. My arm even had spasms. This is just something that is not for me. Sometimes the cure cause additional problems. I believe it is a great product but it is just not for me and other unfortunate ones like me who experience adverse reactions. I must admit it is kind of frightening.
24 Feb 2014
I have just recently went on the generic form and am having all kinds of restless leg from the knee down... like i want to kick someone or crawl out of my skin! The only thing i have changed is to the Generic Cymbalta 90mg... never had this with regular Cymbalta. Feels awful... i just want my real Cymbalta back... i have been on it for over four years!
9 May 2014
Would you tell me what your prescribed for your restless legs and arms syndrome please, Periodic Limb movement syndrome?
I too suffer with this, now not every night, I take Quinine max dosage, for the restless legs part, but am not prescribed anything for the arms when it effects them.
Its awful because it wakes me up some nights, especially when I try to go to bed before 2am, I cannot get to bed before this everynight as it will start and that's me up and down all night long, at least when I go at 2am I get 6hrs straight off with no interruptions.
I would be really very interested to know what you take for this please?
Thanking you in advance.
- Cymbalta Information for Consumers
- Cymbalta Information for Healthcare Professionals (includes dosage details)
- Side Effects of Cymbalta (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
4 answers • 29 Apr 2010
1 answer • 11 May 2011
13 answers • 10 Dec 2011
After recovering from Zevalin I noticed personality/mood changes that I had never had before: depression and anxiety. I had symptoms similar to ...
1 answer • 26 Mar 2013
I have chronic fatigue. Feel tired every second of every day. Just wondering if Lexapro helps fatigue.
2 answers • 11 Nov 2015