Because of joint discomfort, I reduced the frequency of Crestor I was taking from 7 days to every other day during the week (3-4 total per week); however, my cholesteral started to climb. Within the past month, I have begun taking Welchol also. I take two at lunch and two at dinner. This combined with the Crestor has lowered my cholesteral considerably in only one month. Is there a downside to this regimen?