Why mix Dantrolene with sterile water?

8 Aug 2009

Dantrolene is slightly soluble in water. Its solubility decreases in acidic conditions, hence water is preferred to saline.

8 Aug 2009

from http://www.drugs.com/pro/dantrium-intravenous.html
Dantrium is a brand name for dantrolene.

PREPARATION

Each vial of Dantrium Intravenous should be reconstituted by adding 60 mL of sterile water for injection USP (without a bacteriostatic agent), and the vial shaken until the solution is clear. 5% Dextrose Injection USP, 0.9% Sodium Chloride Injection USP, and other acidic solutions are not compatible with Dantrium Intravenous and should not be used. The contents of the vial must be protected from direct light and used within 6 hours after reconstitution. Store reconstituted solutions at controlled room temperature (59°F to 86°F or 15°C to 30°C).