I started cymbalta 2 1/2 weeks ago. I was hoping it would give me some pep. so far, same as usual.
11 Sep 2012
Cymbalta can actually take up to a full month and possibly even longer to really start taking noticeable effect. Everyone's sensitivity to certain drugs is completely different. Cymbalta didn't phase me. Morning, noon, or night I didn't feel any noticeable changes in my level of alertness.
11 Sep 2012
I have been taking Cymbalta for about 6 years and I havent noticed it making any difference. If it does cause you to be sleepy at first, that should subside after about 2 weeks of taking it. FYI, I also recently started Wellbutrin, and it does give you a bit of pep.
11 Sep 2012
Hello deborahdougherty, & welcome to the site. I am assuming that your doctor is prescribing the cymbalta for the depression. Having cfs is a bummer, & sometimes it can take a combination of more than one drug to help with cfs & depresssion. Are you seeing a psychiatrist for your prescriptions? They are the experts when prescribing for depression,& also it takes up to several weeks to get the full benenfit from these type of drugs. If you are not seeing a psychiatirst, that would be my suggestion for you to do. It may take more than one drug to help you with both of these conditions. Wishing you the best ...
11 Sep 2012
Hi, deb! When my psych tried me on Cymbalta I was very drowsy, gained weight, and that was between episodes of severe nausea. After 2 mos we decided it wasn't the drug for me! Just my personal experience...
You might want a little more time to try and adjust, but if you find you don't like the way you feel let your doctor know right away. There are a lot of options available. Everyone is different in their reactions to various meds. Hope you feel better soon!! WildCat
19 Feb 2014
If you really have Chronic Fatigue Syndrome, like I do, Cymbalta will most likely make you feel worse. I have just finished over three weeks or more on the drug, and just decided to go back to the Venlafaxine (Effexor) that was helping my energy a lot, and I'll be taking the dose up to the full 225 mg. I just wanted to try the Cymbalta, as it's for pain. But my fatigue is much more intolerable than the pain, which I take Motrin 800mg and Tramadol daily for. On Cymbalta, my sleep was interrupted about 3 times during the night, and I'd fall back to sleep needing more sleep than normal & feeling really bad the next day. At first I thought maybe it was just a temporary side effect, but it only got worse and not better over 3 weeks. If you are a high strung person with Chronic Fatigue, then maybe it would work for you, but I'd not recommend it for handling fatigue.
22 Sep 2012
I just started Cymbalta 2 days ago. Before starting it I was extremely fatigued all day everyday. I didn't expect to see many results quickly after starting the medication (can take up to 4 weeks or longer to get the full effect) but to my surprise I've already noticed a good improvement. It's taken away my daily aches/pains/cramps along with taking the edge off my anxiety and depression. With my fatigue I've noticed it has also tapered off a little bit. Don't get me wrong, I am still tired but it feels different. Like a sleepy without exhaustion? If that makes sense. Just my little story.
Like everyone else said, everyone reacts differently. I hope the Cymbalta starts giving you the results you want or you find a med that does! Best wishes.
- Cymbalta Information for Consumers
- Cymbalta Information for Healthcare Professionals (includes dosage details)
- Side Effects of Cymbalta (detailed)
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