Crinone - if I put the cream in and in 45 minutes in comes out, what do I do? do I put more back in?

No, you don't put more in. My RN told me that enough will still be absorbed and not to worry about the discharge. She also told me to put it in right before bedtime so it does have more of a chance to work before any of it possible gets discharged. The info. that came in the box with my crinone also said that you are getting the right dosage even if some does come out or even if some stays in the applicator. Hope this helps! Good luck.