15 Nov 2012
Yes, Vyvanse is an amphetamine and it IS excreted in the urine therefore WILL show up on a urine test. Here is what the literature has to say:
Lisdexamfetamine (a prodrug of dextroamphetamine) is converted to l-lysine and dextroamphetamine by first-pass intestinal and/or hepatic metabolism.1
Lisdexamfetamine is not metabolized by CYP isoenzymes.1
Excreted principally in urine.1 Approximately 96% of a 70-mg radiolabeled oral dose of lisdexamfetamine was recovered in urine; parent drug accounted for about 2% of the recovered radioactivity.1
Lisdexamfetamine: <1 hour;1 8 dextroamphetamine: 9.4–13 hours.3 8 30
Note that it does say excreted principally in urine.
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