I have contracted giardia (I am in a bush village in Africa at the moment) and cannot take flagyl - is it a flagyl dirivative? There is a pharmacy but no GP. I will need to get a GP to fax in a script.
Can you take it while on valproic acid (convulex)?
- Posted:
- 30 Jul 2010 by chippy-girl
- Topics:
- flagyl, giardiasis, nitazoxanide, valproic acid, pharmacy
Answers (1)
31 Jul 2010
Hi,
Flagyl altrnative
Doxycycline tablets:
Doxycycline contains the active ingredient doxycycline, which belongs to a group of antibiotics called the tetracyclines. Doxycycline is an antibiotic that has the ability to inhibit the growth of a wide variety of bacteria and certain other organisms. It works by preventing bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. Doxycycline therefore stops the spread of the infection and the remaining bacteria eventually die.
Doxycycline is prescribed to treat:
- Various other infections caprescribed by susceptible bacteria and micro-organisms;
- Urinary tract;
- Eye and sexually transmitted infections;
- A wide variety of respiratory;
Interactions between your selected drugs
valproic acid ↔ nitazoxanide
Applies to: valproic acid, nitazoxanide
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Traement for Giardiasis
I AM NOT A DOCTOR
Tinidazole (Fasigyn)
Adult dosage: 2 g once
Pediatric dosage: 50 mg per kilogram of body weight once (max. 2 g)
Side effects: Side effects similar to metronidazole but appears to be better tolerated and just as effective. Common side effects include bitter taste, vertigo, and GI discomfort. The drug should be taken with food to minimize side effects.
Additional drug facts: Tinidazole was FDA approved. It is another member of the nitro-imidazole family. Health care providers recommend travelers (especially those traveling to Asian countries) buy the drug at the country of their destination and take it in an event of giardia infection.The drug tablets can also be crushed and mixed with cherry syrup (Humco and others) for children. The syrup suspension can be kept at room temperature for 7 days and should be shaken before use
Nitazoxanide
Expand this post...
Adult dosage: 500 mg two times a day for 3 days
Pediatric dosage: 1–3 yrs: 100 mg every 12 hours for 3 days 4–11 yrs: 200 mg every 12 hours for 3 days
Side effects: A variety of side effects were reported but they occurred infrequently in all studies.
Studies failed to provide sufficiently similar results for a comprehensive analysis of the side effects of nitaxonzanide.
Some probable adverse effects include abdominal pain, dyspepsia, constipation, yellow discoloration of urine, dysuria and dry mouth, and dizziness.
The drug should be taken with food to minimize adverse effects.
Additional drug facts: Nitazonxanide is FDA-approved as an oral suspension for treatment of giardiasis. It can be purchased in 500 mg tablets and in oral suspension.
Alternative treatment
Paramomycin (Humatin)
Adult dosage: 25–35 mg per kilogram of body weight per dose, 3 doses per day for 7 days
Pediatric dosage: 25–35 mg per kilogram of body weight per dose, 3 doses per day for 7 days.
Side effects: ototoxicity and nephrotoxicity with systemic administration
Contraindication: Patients with impaired kidney function should use paramomycin with caution
Additional drug facts: Paramomycin is a member of the aminoglycoside family. It inhibits giardia protein synthesis by targeting the 50S and 30S ribosomal subunits. Its activity in vitro is lower than nitroimidazoles; however, because it is poorly absorbed by small intestine, a higher concentration of the drug remains in the lumen to combat giadia organisms. It is also the choice of drug to treat G. lamblia in resistant infection and during pregnancy.
Furazolidone (Furoxone)
Adult dosage: 100 mg four times a day for 7–10 days
Pediatric dosage: 6 mg per kilogram of body weight per dose, 4 doses per day for 7–10 days
Side effects: Gastrointestinal symptoms (nausea, vomiting, diarrhea) are observed in 10% of patients. Other side effects include brown discoloration of urine, and hemolysis in G6PDH-deficient patients.
Additional drug facts: it is a member of the nitrofuran family penetrate body tissues and could be found in saliva, breast milk, semen and vaginal fluid.Not recommended to treating pregnant patients because it has been shown to cause mammary tumor in rats and mutations in bacteria.
Quinacrine
Adult dosage: 100 mg three times a day for 5 days
Pediatric dosage: 2 mg per kilogram of body weight, three times per day for 5 days (max. 300 mg/d)
Side effects: bitter taste and vomiting observed in 28% of study participants; yellow/orange discoloration of the skin, sclerae, and urine. Other common side effects include nausea, vomiting, headache, dizziness and fever. Drug induced psychosis has been observed but is very rare. Dermatitis and drug-induced retinopathy are also uncommon. The drug also acts with lower efficacy in children because the drug has bitter taste and children are less compliant.
Contraindication: Pregnant patients should avoid taking the drug because quinacrine can cross placenta and it might cause spina bifida and renal agenesis in the infant.
The drug, unlike metronidazole, also target cysts.
This drug cannot be obtained commercially.
Albendazole (Albenza)
Adult dosage: 400 mg once a day for 5 days
Pediatric dosage: 15 mg per kilogram of body weight per day for 5 to 7 days (max. 400 mg)
Mebendazole (Vermox)
Adult dosage: 200–400 mg per day for 5 to 10 days[24]
Side effects for Albendazole and Mebendazole: common side effects include anorexia and constipation. Rare side effects include reversible neutropenia and elevated liver function tests. Whether they are terotogenic is unclear
Contraindication of Albendazole and Mebendazole: Albendazole should be taken with caution for pregnant patients because there is a possibility that it might induce tumors. However, animal studies did not reveal increased incidences of cancer.
Additional drug facts: Albendazole and Mebendazole are members of the benzimidazole family. They target G. lamblia by binding to β-tubulin and stopping cytoskeletal formation. It also interferes with glucose uptake of the organism.
I hope this helps.
Thank you for taking the time to help me. I do appreciate it. I will bear your comments in mind. Take care. (stay in Chile it is probably safer there!)
You are more than welcome, let me know how it goes. Stay away from lions... and the winter here is killing me softly!
Take care my friend.
I'LL LIVE! Nomsa the pharmacyst put me on Kantrexil for 2 days. It killed the giardia - and almost killed me too. Now I know why she would only give it to me for 2 days. Anyway thanks for your concern.
By the way there are no lions here only dust, heat, snakes and skorpions.
Send me some snow pleeease!
Stay warm and thanks once again.
Take care - By the way my husband says to say thank you from him as well.
No problem... happy to help!