8 Aug 2009
You could take it together if you really had to, but your doctor would probably put you on low doses of both and monitor you.
Since they both selective serotonin reuptake inhibitors (SSRI's) generally it would not be a good idea to be on both of them.
Fluoxetine and Celexa (citalopram) have a moderate drug interaction between them.
CYP450 3A4 and CYP450 2C19 are the two primary enzymes responsible for the metabolism of citalopram. Concomitant use with a drug that inhibits both the CYP450 3A4 and CYP450 2C19 enzyme systems may decrease the clearance of citalopram and increase its serum concentration. In addition, combination with other selective serotonin reuptake inhibitors (SSRIs) may potentiate the risk of serotonin syndrome due to hyperstimulation of brainstem 5HT1A receptors.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever an enzyme inhibitor is added to or withdrawn from therapy. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
I work full time with lots of stress. i started taking this rx because of anxiety, chest pains, etc. i work for a pharmacy but do not want to talk to ...
1 answer • 14 Jun 2011
... long should I wait between pills? Also heard something about quitting flouxetine slowlly, any suggestions? Have been taking fluoxetine for about ...
1 answer • 9 Nov 2011
In February 2011 my doctor put me on Celexa for mild depression I was having from my parents splitting up. That worked for about a year but I gained ...
3 answers • 3 Mar 2013
I have been on Fluoxetine for 3 years, and it eased the depression and anxiety quite a bit, but not enough. So they put me on Buspirone 10mg 3 times ...
3 answers • 27 Oct 2015