8 Aug 2009
You could take it together if you really had to, but your doctor would probably put you on low doses of both and monitor you.
Since they both selective serotonin reuptake inhibitors (SSRI's) generally it would not be a good idea to be on both of them.
Fluoxetine and Celexa (citalopram) have a moderate drug interaction between them.
CYP450 3A4 and CYP450 2C19 are the two primary enzymes responsible for the metabolism of citalopram. Concomitant use with a drug that inhibits both the CYP450 3A4 and CYP450 2C19 enzyme systems may decrease the clearance of citalopram and increase its serum concentration. In addition, combination with other selective serotonin reuptake inhibitors (SSRIs) may potentiate the risk of serotonin syndrome due to hyperstimulation of brainstem 5HT1A receptors.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever an enzyme inhibitor is added to or withdrawn from therapy. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
1 answer • 6 Apr 2010
I work full time with lots of stress. i started taking this rx because of anxiety, chest pains, etc. i work for a pharmacy but do not want to talk to ...
1 answer • 14 Jun 2011
I have heard alot about the Seretonin Syndrome and I know that both Celexa and Luvox are SSRI's but a psych. just put me on celexa and well i ...
4 answers • 27 Jun 2011
... long should I wait between pills? Also heard something about quitting flouxetine slowlly, any suggestions? Have been taking fluoxetine for about ...
1 answer • 9 Nov 2011
Just had an emergency phych appointment (yes and its Sunday). First consultation. Went through all my history from 0 to today, which I absolutely ...
4 answers • 27 May 2012