8 Aug 2009
You could take it together if you really had to, but your doctor would probably put you on low doses of both and monitor you.
Since they both selective serotonin reuptake inhibitors (SSRI's) generally it would not be a good idea to be on both of them.
Fluoxetine and Celexa (citalopram) have a moderate drug interaction between them.
CYP450 3A4 and CYP450 2C19 are the two primary enzymes responsible for the metabolism of citalopram. Concomitant use with a drug that inhibits both the CYP450 3A4 and CYP450 2C19 enzyme systems may decrease the clearance of citalopram and increase its serum concentration. In addition, combination with other selective serotonin reuptake inhibitors (SSRIs) may potentiate the risk of serotonin syndrome due to hyperstimulation of brainstem 5HT1A receptors.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever an enzyme inhibitor is added to or withdrawn from therapy. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
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1 answer • 6 Apr 2010
... switched me to fluoxetine after taking paxil for 10 years, just cold turkey no step down then change and I have been having all kinds of crazy ...
3 answers • 28 Jun 2010
In February 2011 my doctor put me on Celexa for mild depression I was having from my parents splitting up. That worked for about a year but I gained ...
3 answers • 3 Mar 2013
L-Phenyalalaine helps the neurotransmitters. Thought it would give the fluoxetine a boost.
1 answer • 21 Feb 2014