Can you take celebrex whilst on warfarin medication?

Question is Closed Report Mark as Favorite

Answers (1)

22 Sep 2010

Applies to: warfarin, Celebrex (celecoxib)

MONITOR: Coadministration with celecoxib may infrequently enhance the hypoprothrombinemic effect of warfarin. The proposed mechanism is competitive inhibition of the CYP450 2C9 metabolism of warfarin by celecoxib, as both drugs are substrates of this isoenzyme. A study involving 24 healthy volunteers found no effect of celecoxib (200 mg twice daily) on the prothrombin time or steady-state pharmacokinetics of warfarin. However, there have been isolated post-marketing case reports of elderly patients stabilized on warfarin who developed INR increases and/or bleeding complications following the addition of celecoxib. It is possible that patients with variant alleles resulting in reduced CYP450 2C9 metabolism (i.e., CYP450 2C9 poor metabolizers) may be at increased risk for this interaction, since they have reduced clearance of both celecoxib and warfarin.

Expand...

Votes: +0

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

Is celebrex available in a patch form?

My mother recently had a knee replacement. With all the pain meds she was prescribed she developed an ulcer. She has been taking Celebrex for many ...

1 answer 18 Oct 2010

Warfarin - making my husband feel dizzy & terrible, what else could he take instead?

My husband has been on Warfarin for about 2 months due to multiple PE's in his lungs. For the past month he has been getting terrible bouts of ...

3 answers 1 May 2011

Is a constant headache & swollen feet an after effect of a mild stroke or a side effect of warfarin?

Or taking too high a dose of warfarin? My mother has both and yet had neither before being put on the warfarin, which they keep increasing in ...

2 answers 5 Jul 2011