Skip to Content

Can you take celebrex whilst on warfarin medication?

Question is Closed
Report Favorite

Answers (1)

22 Sep 2010

Applies to: warfarin, Celebrex (celecoxib)

MONITOR: Coadministration with celecoxib may infrequently enhance the hypoprothrombinemic effect of warfarin. The proposed mechanism is competitive inhibition of the CYP450 2C9 metabolism of warfarin by celecoxib, as both drugs are substrates of this isoenzyme. A study involving 24 healthy volunteers found no effect of celecoxib (200 mg twice daily) on the prothrombin time or steady-state pharmacokinetics of warfarin. However, there have been isolated post-marketing case reports of elderly patients stabilized on warfarin who developed INR increases and/or bleeding complications following the addition of celecoxib. It is possible that patients with variant alleles resulting in reduced CYP450 2C9 metabolism (i.e., CYP450 2C9 poor metabolizers) may be at increased risk for this interaction, since they have reduced clearance of both celecoxib and warfarin.


Votes: +0

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

Chronic medication - Celebrex?

I have been on Vioxx then Celebrex for approx. 17-18 years nows, with a break for 4 years. I suffer from osteoarthritis, chronic fatigue and low ...

2 answers 20 Nov 2010

Warfarin - making my husband feel dizzy & terrible, what else could he take instead?

My husband has been on Warfarin for about 2 months due to multiple PE's in his lungs. For the past month he has been getting terrible bouts of ...

3 answers 1 May 2011

All medication my mother is currently taking she already on?

It was not until she started on warfarin that she had the headaches or swollen feet. Her doctor appears to regard me as a nuisance, as every time I ...

2 answers 5 Jul 2011

Do you help people with affording their medication I take demopresson for diabetics insipidus?

and the cost is 54.00 for 20 tablets and I was told it was 300,00 for a month supply that is crazy as spend 200.00 for my celebrex an month.

2 answers 21 May 2013