bbbostonCurrently on 60mg of prozac ( 5 yrs ) was supplemented with doxepin, 75mg, due to reaccuring symptoms of severe depression. Is this safe?
Can you safely be on both prozac and doxepin?
- Posted:
- 9 Mar 2010 by bbboston
- Topics:
- prozac, depression, anxiety, obsessive compulsive disorder, doxepin
Details:
Answers (2)
suzanne6618 Mar 2010
There is considerable risk taking both your medicines together and generally the combination should be avoided unless the benefits outweigh the risks.
See the below link for details of the potential drug interaction.
If I was you I would be talking with your doctor. Good luck.
See: http://www.drugs.com/interactions-check.php
19 Mar 2012
NO safe to take both drugs beacuse Coadministration with fluoxetine may significantly increase the plasma concentrations of some tricyclic antidepressants (TCAs). The proposed mechanism is fluoxetine inhibition of CYP450 2D6, the isoenzyme responsible for the metabolic clearance of many antidepressant and psychotropic drugs. Seizures and delirium have been reported, as well as a fatality attributed to fluoxetine-induced chronic amitriptyline toxicity. Pharmacodynamically, the combination of fluoxetine (or any other selective serotonin reuptake inhibitor) and a TCA may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors
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Thanks so much for the imput!!! I was doing some research on my own and felt the same way!! I actually did not take it yet and am seeing my doctor today to increase my prozac first. I have had such good results with prozac I really do not want to try something else. I did that once and it was a total flop. I will keep you posted :} thanks again